戊型肝炎疫苗。
Hepatitis E vaccine.
机构信息
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Rae Bareilly Road, Lucknow, 226 014, India.
出版信息
Hepatol Int. 2008 Sep;2(3):308-15. doi: 10.1007/s12072-008-9071-4. Epub 2008 Apr 10.
Abstract
Hepatitis E is an emerging disease in resource-poor regions of the world. It is estimated that about 2 billion people live in areas endemic for this disease. The inability to reproducibly culture hepatitis E virus makes it impossible to develop traditional live or inactivated vaccines. However, significant progress has been made in developing and testing recombinant subunit vaccines based on the viral capsid protein. This review summarizes these efforts.
摘要
戊型肝炎是一种在世界资源匮乏地区新出现的疾病。据估计，约有 20 亿人生活在这种疾病流行的地区。由于无法重复培养戊型肝炎病毒，因此无法开发传统的活疫苗或灭活疫苗。然而，基于病毒衣壳蛋白的重组亚单位疫苗的开发和试验已经取得了重大进展。本文综述了这些努力。
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本文引用的文献
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Vaccine. 2007 May 30;25(22):4350-60. doi: 10.1016/j.vaccine.2007.03.040. Epub 2007 Apr 9.
2
Safety and efficacy of a recombinant hepatitis E vaccine.重组戊型肝炎疫苗的安全性和有效性。
N Engl J Med. 2007 Mar 1;356(9):895-903. doi: 10.1056/NEJMoa061847.
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A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates.一种细菌表达的戊型肝炎颗粒疫苗：对灵长类动物的抗原性、免疫原性和保护性。
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