Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Rae Bareilly Road, Lucknow, 226 014, India.
Hepatol Int. 2008 Sep;2(3):308-15. doi: 10.1007/s12072-008-9071-4. Epub 2008 Apr 10.
Hepatitis E is an emerging disease in resource-poor regions of the world. It is estimated that about 2 billion people live in areas endemic for this disease. The inability to reproducibly culture hepatitis E virus makes it impossible to develop traditional live or inactivated vaccines. However, significant progress has been made in developing and testing recombinant subunit vaccines based on the viral capsid protein. This review summarizes these efforts.
戊型肝炎是一种在世界资源匮乏地区新出现的疾病。据估计，约有 20 亿人生活在这种疾病流行的地区。由于无法重复培养戊型肝炎病毒，因此无法开发传统的活疫苗或灭活疫苗。然而，基于病毒衣壳蛋白的重组亚单位疫苗的开发和试验已经取得了重大进展。本文综述了这些努力。
