2,4-甲苯二胺诱导的细菌致突变性、仓鼠细胞转化与致癌性的相关性。
Correlation of bacterial mutagenicity and hamster cell transformation with tumorigenicity induced by 2,4-toluenediamine.
作者信息
Pienta R J, Shah M J, Lebherz W B, Andrews A W
出版信息
Cancer Lett. 1977 Jul;3(1-2):45-52. doi: 10.1016/s0304-3835(77)94028-9.
PMID:196749
Abstract
In the presence of rat liver microsome enzymes, 2,4-toluenediamine (TDA) was mutagenic for several tester strains of Salmonella typhimurium. TDA induced morphological transformation in an in vitro carcinogenesis system using secondary culture target cells prepared from cryopreserved primary Syrian hamster embryo cells. These results now correlate bacterial mutagenicity and in vitro morphological transformation with the reported tumorigenicity of this compound.
摘要
在大鼠肝脏微粒体酶存在的情况下，2,4 - 甲苯二胺（TDA）对几种鼠伤寒沙门氏菌测试菌株具有致突变性。在使用从冷冻保存的原代叙利亚仓鼠胚胎细胞制备的二次培养靶细胞的体外致癌系统中，TDA诱导了形态转化。这些结果现在将细菌致突变性和体外形态转化与该化合物已报道的致瘤性联系起来。
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