Institute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Eur J Nutr. 2010 Mar;49(2):65-71. doi: 10.1007/s00394-009-0049-3. Epub 2009 Aug 13.
Lupin protein had hypocholesterolemic effects in laboratory animals. However, the effect in humans has not been elucidated till now.
To investigate the effect of lupin protein on circulating cholesterol in plasma and lipoproteins of hypercholesterolemic subjects.
A randomised, double-blind, placebo-controlled, parallel trial (23 females and 20 males completed the trial) was conducted to compare the effects of lupin protein versus casein as control protein on plasma lipids and amino acids. Thirty-five grams of the test protein were consumed daily for 6 weeks.
Both lupin protein and casein resulted in a reduction of circulating plasma cholesterol (-0.50 +/- 0.64 and -0.47 +/- 0.79 mM; P < 0.05) from baseline to week 6. The reduction of plasma cholesterol was mainly caused by a reduction of LDL cholesterol in the lupin protein group (-0.31 +/- 0.46 mM; P < 0.05), while in the casein group HDL cholesterol significantly declined (-0.17 +/- 0.15 mM; P < 0.05). Comparing the lupin protein group with the casein group yielded a difference in the net changes from baseline to week 6 in the LDL:HDL cholesterol-ratio of -0.24 (95% CI: -0.007, -0.479; P < 0.05). No significant differences in net changes were observed for plasma concentrations of triglycerides, glucose, homocysteine, taurine and most of the amino acids.
Lupin protein compared to casein slightly lowered the concentration of LDL cholesterol in hypercholesterolemic subjects, without altering HDL cholesterol. No or minor effects of lupin protein were observed on circulating glucose, homocysteine and plasma amino acids.
羽扇豆蛋白在实验动物中有降低胆固醇的作用。然而，其在人类中的效果至今仍不清楚。
研究羽扇豆蛋白对高胆固醇血症患者血浆胆固醇和脂蛋白中循环胆固醇的影响。
进行了一项随机、双盲、安慰剂对照、平行试验（23 名女性和 20 名男性完成了试验），比较了羽扇豆蛋白与对照蛋白酪蛋白对血浆脂质和氨基酸的影响。每天食用 35 克试验蛋白，持续 6 周。
羽扇豆蛋白和酪蛋白均使循环血浆胆固醇从基线到第 6 周降低（-0.50±0.64 和-0.47±0.79mM；P<0.05）。血浆胆固醇的降低主要是由于 LDL 胆固醇的降低（-0.31±0.46mM；P<0.05），而在酪蛋白组中 HDL 胆固醇显著下降（-0.17±0.15mM；P<0.05）。将羽扇豆蛋白组与酪蛋白组进行比较，从基线到第 6 周的 LDL：HDL 胆固醇比值的净变化差异为-0.24（95%CI：-0.007，-0.479；P<0.05）。血浆甘油三酯、葡萄糖、同型半胱氨酸、牛磺酸和大多数氨基酸的净变化无显著差异。
与酪蛋白相比，羽扇豆蛋白略微降低了高胆固醇血症患者 LDL 胆固醇的浓度，而不改变 HDL 胆固醇。羽扇豆蛋白对循环葡萄糖、同型半胱氨酸和血浆氨基酸无或仅有轻微影响。
