Staab Benedict, Eick Sigrun, Knöfler Gerhild, Jentsch Holger
Department of Conservative Dentistry and Periodontology, Medical Faculty, University of Leipzig, Leipzig, Germany.
J Clin Periodontol. 2009 Oct;36(10):850-6. doi: 10.1111/j.1600-051X.2009.01459.x. Epub 2009 Aug 12.
The aim of this study was to determine the effect of a probiotic milk drink on gingival health and the development of experimental gingivitis.
Fifty volunteer students took part in a parallel-designed non-blinded study. The test group drank a probiotic drink once a day; the control group did not receive any product to drink. After 8 weeks, individual mechanical plaque control was interrupted for 96 h. Papilla bleeding index, interproximal plaque and Turesky plaque index (PI) were recorded at baseline, after 8 weeks and again 96 h later. At the same time points, gingival crevicular fluid had been collected for analysis of polymorphonuclear elastase, myeloperoxidase (MPO) and matrix metalloproteinase-3 (MMP-3).
Interproximal PI and papillary bleeding were not different between the groups. In the test group, elastase activity and MMP-3 amount were significantly lower after the intake of the probiotic milk drink (p<0.001 and 0.016). There was a significant increase of MPO activity in the control group; both groups were different at the end of the study (p=0.014).
The data suggest a beneficial effect of the probiotic milk drink on gingival inflammation.
本研究旨在确定一种益生菌乳饮料对牙龈健康及实验性牙龈炎发展的影响。
五十名志愿学生参与了一项平行设计的非盲法研究。试验组每天饮用一次益生菌饮料；对照组不饮用任何产品。8周后，个体机械性菌斑控制中断96小时。在基线、8周后及96小时后再次记录龈乳头出血指数、邻面菌斑及Turesky菌斑指数（PI）。在相同时间点，收集龈沟液以分析多形核弹性蛋白酶、髓过氧化物酶（MPO）和基质金属蛋白酶-3（MMP-3）。
两组间邻面PI和龈乳头出血无差异。在试验组中，摄入益生菌乳饮料后弹性蛋白酶活性和MMP-3含量显著降低（p<0.001和0.016）。对照组MPO活性显著增加；两组在研究结束时存在差异（p=0.014）。
数据表明益生菌乳饮料对牙龈炎症有有益作用。
