Sanquin Blood Supply Foundation: Blood Bank Region Northwest, Amsterdam, the Netherlands.
Vox Sang. 2009 Nov;97(4):355-7. doi: 10.1111/j.1423-0410.2009.01221.x. Epub 2009 Aug 4.
The BacT/ALERT system for bacterial monitoring of platelet concentrates (PCs) was introduced in the Netherlands in 2001. Samples are cultured for 7 days, and as a result of the short shelf-life of PCs, they are usually released as 'negative to date'. Therefore, some of the PCs have already been transfused at the moment of a positive signal in continued cultures in the BacT/Alert. It is unclear, however, whether these PCs are associated with more transfusion reactions.
During a 2-year period clinical data were collected from all patients who received PCs released as 'negative to date' but with a positive bacterial culture after being transfused.
Data of 158 patients who received PCs with confirmed positive bacterial culture tests were analysed. Two patients developed a transfusion reaction. In both PCs, Propionibacterium was cultured. The imputability as related to the transfusion was classified as unlikely in both patients.
Two of 158 transfusions of PCs released as 'negative to date', but with a confirmed positive BacT/ALERT result, were initially associated with transfusion reactions. However, the imputability of both reactions was low.
2001 年，BacT/ALERT 系统被引入荷兰，用于监测血小板浓缩物（PCs）中的细菌。样本培养 7 天，由于 PCs 的保质期短，它们通常在 BacT/Alert 中继续培养出现阳性信号时被“释放为阴性”。然而，目前尚不清楚这些 PCs 是否与更多的输血反应有关。
在为期 2 年的时间里，收集了所有接受过“释放为阴性”但在输血后阳性细菌培养的 PC 治疗的患者的临床数据。
对 158 例经证实的阳性细菌培养试验的 PC 患者的数据进行了分析。两名患者发生了输血反应。在这两例 PC 中，均培养出丙酸杆菌。两名患者的输血反应都被归类为可能性不大。
在 158 例“释放为阴性”但 BacT/ALERT 结果确认为阳性的 PC 输血中，有 2 例最初与输血反应相关。然而，这两种反应的关联性都较低。
