富含血浆的自体单采血小板的延长保存。
Extended storage of autologous apheresis platelets in plasma.
机构信息
Puget Sound Blood Center, Seattle, WA 98104-1256, USA.
出版信息
Vox Sang. 2013 May;104(4):324-30. doi: 10.1111/vox.12010. Epub 2013 Feb 6.
BACKGROUND AND OBJECTIVES
The purpose of our studies was to determine the effects of extended platelet storage on poststorage platelet viability.
MATERIALS AND METHODS
Normal subjects were recruited to donate platelets using two different apheresis systems: either the COBE Spectra (n = 58) or the Haemonetics MCS+ (n = 84). Platelet recovery and survival data from the two systems were compared with each other and with in vitro measurements of the stored platelets.
RESULTS
There were no significant differences in either platelet recoveries or survivals between the two machines between 1 and 8 days of storage. Combining the data from both machines, platelet recoveries decreased by 2.6% and survivals by 0.3 days/storage day. In vitro assays did not predict either platelet recoveries or survivals during storage for 5-8 days. After 9 days of storage, pHs were unacceptable (≤ 6.1), suggesting that 8 days will be the longest possible storage time.
CONCLUSIONS
These data suggest that, if stored platelet bacterial contamination issues are resolved, significant extension of platelet storage times is possible.
背景和目的
我们研究的目的是确定延长血小板储存时间对储存后血小板活力的影响。
材料和方法
招募正常受试者使用两种不同的单采系统捐献血小板：COBE Spectra（n = 58）或 Haemonetics MCS+（n = 84）。比较两种系统的血小板回收率和存活率数据，并与体外储存血小板的测量值进行比较。
结果
在 1 至 8 天的储存期间，两种机器的血小板回收率或存活率均无显著差异。将两种机器的数据合并，血小板回收率下降 2.6%，存活率每储存 1 天下降 0.3 天。体外检测不能预测储存 5-8 天期间的血小板回收率或存活率。储存 9 天后，pH 值不可接受（≤6.1），这表明 8 天可能是最长的储存时间。
结论
这些数据表明，如果解决了储存血小板的细菌污染问题，则有可能显著延长血小板的储存时间。
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