Department of Microbiology, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras.
Cancer Causes Control. 2009 Nov;20(9):1663-70. doi: 10.1007/s10552-009-9414-z. Epub 2009 Aug 15.
This study was aimed at estimating type-specific HPV prevalence and its cofactors among Honduran women with normal cytology in order to provide valuable information to health policymakers about the epidemiology of this important sexually transmitted infection.
A total of 591 women with normal cytology from Tegucigalpa, Honduras were interviewed and tested for HPV using the SPF10 LiPA25. A structured epidemiological questionnaire was administered to each woman.
The overall HPV prevalence was 51%. Twenty-three types of HPV were detected; HPV 16, 51, 31, 18, and 11 were the most common. The highest prevalence of cancer associated HPV types (15.0%) was found in the women less than 35 years. Besides the association with age, the main independent predictors of HPV infection were the lifetime number of sexual partners and having a low socioeconomic status and less than 5 previous Pap smears.
In the population studied, there was a broad diversity of HPV infections, with high-risk types being the most common types detected. The establishment of a well-characterized population with regard to the community prevalence of type-specific HPV infection will provide a valuable baseline for monitoring population effectiveness of an HPV vaccine.
本研究旨在估计洪都拉斯细胞学正常的女性中 HPV 型别特异性流行率及其影响因素，以便为卫生政策制定者提供有关这种重要性传播感染的流行病学信息。
对来自洪都拉斯特古西加尔巴的 591 名细胞学正常的女性进行了访谈，并使用 SPF10 LiPA25 对 HPV 进行了检测。对每位女性都进行了结构流行病学问卷调查。
总体 HPV 流行率为 51%。共检测到 23 种 HPV，HPV 16、51、31、18 和 11 最为常见。与年龄相关的最高癌症相关 HPV 型别流行率（15.0%）见于 35 岁以下的女性。除了与年龄相关外，HPV 感染的主要独立预测因素为性伴侣终身数量、社会经济地位较低以及巴氏涂片检查次数少于 5 次。
在所研究的人群中，HPV 感染呈广泛多样性，高危型别是最常见的检出型别。建立具有明确特征的特定型别 HPV 社区流行率人群，将为 HPV 疫苗的人群效果监测提供有价值的基线。
