Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089-9175, USA.
Cancer Causes Control. 2009 Nov;20(9):1645-51. doi: 10.1007/s10552-009-9412-1. Epub 2009 Aug 15.
Growing evidence that ultrafine particles in ambient air can cause brain lesions in animals led us to investigate whether particulate components of air pollution may be associated with brain cancer risk in humans. Air pollution has been associated with respiratory disorders and cardiovascular morbidity and mortality, but associations between air pollutants and brain cancer have not been investigated in adults.
The analyses included 1,284 deaths due to brain cancer from the Cancer Prevention Study-II, an ongoing prospective mortality study of adults in the United States and Puerto Rico conducted by the American Cancer Society. Air pollution data from national databases for metropolitan areas were combined with residential history and vital status data to estimate exposure to particulate and gaseous air pollution.
We found no elevated risk for estimated measures of air pollutants, an unanticipated reduction in risk was found between gaseous air pollutants and brain cancer mortality.
The findings do not provide evidence of increased risk of brain cancer mortality due to air pollutants.
越来越多的证据表明，环境空气中的超细颗粒会导致动物的脑部损伤，这促使我们研究空气污染的颗粒成分是否与人类的脑癌风险有关。空气污染与呼吸疾病和心血管发病率及死亡率有关，但尚未在成年人中研究空气污染物与脑癌之间的关联。
分析包括来自癌症预防研究-II的 1284 例因脑癌导致的死亡，这是美国癌症协会在美国和波多黎各进行的一项正在进行的前瞻性成年人死亡率研究。将来自国家数据库的大气污染数据与居住史和生命状态数据相结合，以估算对颗粒物和气体空气污染的暴露。
我们没有发现空气污染物的估计指标存在风险升高，相反，在气体空气污染物与脑癌死亡率之间发现了意外的降低风险。
这些发现并没有提供证据表明空气污染物会导致脑癌死亡率增加。
