School of Psychology, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Dev Psychobiol. 2009 Nov;51(7):533-43. doi: 10.1002/dev.20391.
This experiment used event-related potentials (ERPs) to investigate the neural processes underlying the development of response inhibition in a modified version of the go/no-go paradigm [Cragg and Nation [2008] Developmental Science 11(6): 819-827]. N2 and P3 ERP components on correct go trials and partial and successful inhibitions were compared in 7- and 9-year-old children. A larger N2 effect on successful inhibitions was found in 9-year-olds compared to 7-year-olds at fronto-central electrodes. N2 amplitude was positively related to behavioral performance in the 7-year-olds suggesting it may reflect inhibitory processes; however, this relationship was not present in the 9-year-olds. Age differences were also apparent in the go P3, perhaps indicating differences in stimulus processing. The no-go P3 component was larger on successful than partial inhibitions. In contrast, there was no difference in N2 amplitude between partial and successful inhibitions. A significant difference was found in N2 latency however. This suggests that inhibitory processes are similar in both cases but initiated earlier on successful inhibitions. N2 latency was also shorter in 9-year-olds than 7-year-olds supporting an increase in the efficiency of response inhibition with age.
本实验采用事件相关电位（ERPs）技术，在改良的 Go/No-Go 范式中研究反应抑制发展的神经过程[Cragg 和 Nation [2008]发展科学 11(6): 819-827]。在 7 岁和 9 岁儿童中，对正确 Go 试验和部分及成功抑制的 N2 和 P3 ERP 成分进行了比较。与 7 岁儿童相比，9 岁儿童在前额中央电极上的成功抑制产生了更大的 N2 效应。N2 幅度与 7 岁儿童的行为表现呈正相关，表明它可能反映了抑制过程；然而，这种关系在 9 岁儿童中并不存在。在 Go P3 中也出现了年龄差异，这可能表明刺激处理存在差异。成功抑制的 No-Go P3 成分大于部分抑制。相比之下，部分抑制和成功抑制之间的 N2 幅度没有差异。然而，潜伏期存在显著差异。这表明在两种情况下抑制过程相似，但成功抑制时更早开始。N2 潜伏期在 9 岁儿童中也比 7 岁儿童短，支持随着年龄的增长反应抑制效率的提高。
