Division of Dermatology, Department of Medicine, Srinagarind Hospital Medical School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
J Eur Acad Dermatol Venereol. 2010 Feb;24(2):168-72. doi: 10.1111/j.1468-3083.2009.03377.x. Epub 2009 Aug 14.
Topical aloe vera (AV) has been used to treat various skin conditions, including psoriasis, with good results.
This study aims to compare the efficacy of AV and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis.
A randomized, comparative, double-blind, 8-week study was designed. Eighty patients randomly received AV or 0.1% TA cream and their clinical response were evaluated using the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI).
After 8 weeks of treatment, the mean PASI score decreased from 11.6 to 3.9 (-7.7) in the AV group and from 10.9 to 4.3 (-6.6) in the TA group. Between-group difference was 1.1 (95% confidence interval -2.13, -0.16, P = 0.0237). The mean DLQI score decreased from 8.6 to 2.5 (-6.1) in the AV group and from 8.1 to 2.3 (-5.8) in the TA group. Between-group difference was 0.3 (95% confidence interval -1.18, -0.64, P = 0.5497). There was no follow-up period after the 8-week treatment.
AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis; however, both treatments have similar efficacy in improving the quality of life of patients with mild to moderate psoriasis.
局部使用芦荟已被用于治疗各种皮肤疾病，包括银屑病，疗效良好。
本研究旨在比较芦荟和 0.1%曲安奈德（TA）治疗轻度至中度斑块状银屑病的疗效。
设计了一项随机、对照、双盲、8 周的研究。80 例患者随机接受芦荟或 0.1%TA 乳膏治疗，并采用银屑病面积严重程度指数（PASI）和皮肤病生活质量指数（DLQI）评估其临床疗效。
治疗 8 周后，芦荟组 PASI 评分从 11.6 降至 3.9（-7.7），TA 组从 10.9 降至 4.3（-6.6）。组间差异为 1.1（95%置信区间-2.13，-0.16，P=0.0237）。芦荟组 DLQI 评分从 8.6 降至 2.5（-6.1），TA 组从 8.1 降至 2.3（-5.8）。组间差异为 0.3（95%置信区间-1.18，-0.64，P=0.5497）。治疗 8 周后没有随访期。
芦荟乳膏可能比 0.1%TA 乳膏更能有效减轻银屑病的临床症状；然而，两种治疗方法在改善轻度至中度银屑病患者的生活质量方面均具有相似的疗效。
