Department of Biology, College of Food Science and Biotechnology, Zhejiang Gongshang University, Food Safety Key Lab of Zhejiang Province, Hangzhou 310035, China.
Fitoterapia. 2010 Mar;81(2):93-6. doi: 10.1016/j.fitote.2009.08.007. Epub 2009 Aug 15.
Ganoderma lucidum is a traditional medicinal herb used to treat various diseases in China and Southeast Asia for thousands of years. An aqueous glycopeptide, LZ-B-1, was prepared by successive chromatography and exhibited an immunostimulating potential. To better understand the mechanism of bioactivity for this compound, the polysaccharide moiety of glycopeptide LZ-B-1 was studied by NMR spectroscopy. The results indicated that the polysaccharide moiety had a backbone of 1,6-disubstituted-alpha-galactopyranosyl, 1,2,6-trisubstituted-alpha-galactopyranosyl, 1,3-disubstituted-beta-glucopyranosyl and 1,4,6-trisubstituted-beta-glucopyranosyl residues. The branches were mainly composed of 1-substituted-beta-glucopyranosyl and 1-substituted-alpha-fucopyranosyl residues.
灵芝是一种传统的药用草药，在中国和东南亚地区被用于治疗各种疾病已有数千年的历史。一种水溶性糖肽 LZ-B-1 通过连续色谱法制备，并表现出免疫刺激潜力。为了更好地理解该化合物的生物活性机制，通过 NMR 光谱研究了糖肽 LZ-B-1 的多糖部分。结果表明，多糖部分具有 1,6-二取代-α-半乳糖吡喃基、1,2,6-三取代-α-半乳糖吡喃基、1,3-二取代-β-吡喃葡萄糖基和 1,4,6-三取代-β-吡喃葡萄糖基残基的主链。支链主要由 1-取代-β-吡喃葡萄糖基和 1-取代-α-岩藻糖基残基组成。
