Asgari Maryam M, Maruti Sonia S, Kushi Lawrence H, White Emily
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Arch Dermatol. 2009 Aug;145(8):879-82. doi: 10.1001/archdermatol.2009.176.
To examine whether antioxidant supplement use is associated with melanoma risk in light of recently published data from the Supplementation in Vitamins and Mineral Antioxidants (SUVIMAX) study, which reported a 4-fold higher melanoma risk in women randomized to receive a supplement with nutritionally appropriate doses of antioxidants.
Population-based prospective study (Vitamins and Lifestyle [VITAL] cohort).
Western Washington State.
A total of 69 671 men and women who self-reported (1) intake of multivitamins and supplemental antioxidants, including selenium and beta carotene, during the past 10 years and (2) melanoma risk factors on a baseline questionnaire. Main Outcome Measure Incident melanoma identified through linkage to the Surveillance, Epidemiology, and End Results (SEER) cancer registry.
Cox proportional hazards regression models were used to estimate multivariable relative risks (RRs) and 95% confidence intervals (CIs) for multivitamin, supplemental selenium, and supplemental beta carotene use. After adjusting for melanoma risk factors, we did not detect a significant association between multivitamin use and melanoma risk in women (RR, 1.14; 95% CI, 0.78-1.66) or in men (RR, 1.09; 95% CI, 0.83-1.43). Moreover, we did not observe increased melanoma risk with the use of supplemental beta carotene (RR, 0.87; 95% CI, 0.48-1.56) or selenium (RR, 0.98; 95% CI, 0.69-1.41) at doses comparable with those of the SUVIMAX study. Conclusion Antioxidants taken in nutritional doses do not seem to increase melanoma risk.
鉴于最近发表的维生素和矿物质抗氧化剂补充剂（SUVIMAX）研究数据，探讨使用抗氧化剂补充剂是否与黑色素瘤风险相关。该研究报告称，随机接受营养适当剂量抗氧化剂补充剂的女性患黑色素瘤的风险高出4倍。
基于人群的前瞻性研究（维生素与生活方式[VITAL]队列）。
华盛顿州西部。
共有69671名男性和女性，他们在基线问卷中自我报告了（1）过去10年中多种维生素和补充抗氧化剂（包括硒和β-胡萝卜素）的摄入量，以及（2）黑色素瘤风险因素。主要结局指标通过与监测、流行病学和最终结果（SEER）癌症登记处的数据关联确定的新发黑色素瘤。
使用Cox比例风险回归模型估计多种维生素、补充硒和补充β-胡萝卜素使用的多变量相对风险（RR）和95%置信区间（CI）。在调整黑色素瘤风险因素后，我们未发现女性（RR，1.14；95%CI，0.78 - 1.66）或男性（RR，1.09；95%CI，0.83 - 1.43）使用多种维生素与黑色素瘤风险之间存在显著关联。此外，在与SUVIMAX研究剂量相当的情况下，我们未观察到补充β-胡萝卜素（RR，0.87；95%CI，0.48 - 1.56）或硒（RR，0.98；95%CI，0.69 - 1.41）会增加黑色素瘤风险。结论：营养剂量的抗氧化剂似乎不会增加黑色素瘤风险。
