Comstock G W, Helzlsouer K J, Bush T L
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD.
Am J Clin Nutr. 1991 Jan;53(1 Suppl):260S-264S. doi: 10.1093/ajcn/53.1.260S.
In 1974 and 1975, serum specimens were collected from 25,802 volunteers in Washington County, Maryland. The serum was kept frozen at -73 degrees C until the time of assay. Prediagnostic samples from 436 cancer cases and 765 matched control subjects have been assayed. Nine sites have been studied: colon, rectum, pancreas, lung, melanoma, basal cell of skin, breast, prostate, and bladder. Serum beta-carotene levels showed a strong protective association with lung cancer, suggestive protective associations with melanoma and bladder cancer, and a suggestive but nonprotective association with rectal cancer. Serum vitamin E levels had a protective association with lung cancer; none of the other sites showed impressive associations. Low levels of serum lycopene were strongly associated with pancreatic cancer and less strongly associated with cancer of the bladder and rectum.
1974年和1975年，从马里兰州华盛顿县的25802名志愿者身上采集了血清样本。血清保存在-73摄氏度下直至检测时。已对436例癌症病例和765名匹配对照受试者的诊断前样本进行了检测。研究了九个部位：结肠、直肠、胰腺、肺、黑色素瘤、皮肤基底细胞、乳腺、前列腺和膀胱。血清β-胡萝卜素水平与肺癌呈强烈的保护关联，与黑色素瘤和膀胱癌呈提示性保护关联，与直肠癌呈提示性但无保护作用的关联。血清维生素E水平与肺癌呈保护关联；其他部位均未显示出显著关联。血清番茄红素水平低与胰腺癌密切相关，与膀胱癌和直肠癌的相关性较弱。
