Berckmans Barbara, De Veylder Lieven
Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, 9052 Gent, Belgium.
Curr Opin Plant Biol. 2009 Oct;12(5):599-605. doi: 10.1016/j.pbi.2009.07.005. Epub 2009 Aug 21.
Cell division is a highly coordinated process. In the last decades, many plant cell cycle regulators have been identified. Strikingly, only a few transcriptional regulators are known, although a significant amount of the genome is transcribed in a cell cycle phase-dependent manner. E2F-DP transcription factors and three repeat MYB proteins are responsible for the expression of genes at the G1-to-S and G2-to-M transition, respectively. However, these two mechanisms cannot explain completely the transcriptional regulation seen during the cell cycle. Correspondingly, several new transcriptional regulators have been characterized, stressing the importance of transcriptional control during the cell cycle.
细胞分裂是一个高度协调的过程。在过去几十年里，许多植物细胞周期调节因子已被鉴定出来。令人惊讶的是，尽管基因组中有相当一部分是以细胞周期阶段依赖性方式转录的，但已知的转录调节因子却很少。E2F-DP转录因子和三个重复的MYB蛋白分别负责G1期到S期和G2期到M期基因的表达。然而，这两种机制并不能完全解释细胞周期中所见的转录调控。相应地，几个新的转录调节因子已被鉴定，这凸显了细胞周期中转录控制的重要性。
