Banes A J, Smith R E
Infect Immun. 1977 Jun;16(3):876-84. doi: 10.1128/iai.16.3.876-884.1977.
Chicks infected as 12-day-old embryos with an end-point purified derivative of avian myeloblastosis virus developed a rapidly progressive osteopetrosis that manifested within 1 week of hatching. A detailed comparison of osteopetrotic chicks and normal hatchmates revealed the following. (i) Osteopetrotic chicks exhibited a stunting syndrome, growing at a mean rate that was 26% of the control rats. (ii) At autopsy, the mass of the lymphoid organs was reduced, whereas the mass of the heart, pancreas, kidneys, lungs, brain, liver, and bones of osteopetrotic chicks was increased. Edema was likely responsible for most of the increase in organ weight. (iii) Infected chicks exhibited a normochromic, normocytic anemia that was virus dose dependent and was not required for the development of osteopetrosis. (iv) Bone collagen content was normal. (v) Osteopetrotic bone was initially hypomineralized, but later became more fully mineralized. (vi) The concentrations of alpha, beta, and gamma globulins in the plasma were elevated in osteopetrotic chicks, whereas albumin concentration was decreased. (vii) The level of plasma alkaline phosphatase was elevated in osteopetrotic chicks, yet the level of acid phosphatase was unchanged. (viii) Body and bone temperatures were unchanged.
12日龄胚胎感染禽成髓细胞瘤病毒终点纯化衍生物的雏鸡，在孵化后1周内出现快速进展的骨质石化。对患骨质石化的雏鸡和正常同窝雏鸡进行详细比较，结果如下：(i)患骨质石化的雏鸡表现出发育迟缓综合征，平均生长速度仅为对照雏鸡的26%。(ii)尸检时，淋巴器官质量减轻，而患骨质石化的雏鸡的心脏、胰腺、肾脏、肺、脑、肝脏和骨骼质量增加。水肿可能是器官重量增加的主要原因。(iii)受感染的雏鸡表现出正色素正细胞性贫血，其与病毒剂量有关，且骨质石化的发展并不需要贫血。(iv)骨胶原含量正常。(v)患骨质石化的骨骼最初矿化不足，但后来矿化更完全。(vi)患骨质石化的雏鸡血浆中α、β和γ球蛋白浓度升高，而白蛋白浓度降低。(vii)患骨质石化的雏鸡血浆碱性磷酸酶水平升高，但酸性磷酸酶水平未变。(viii)体温和骨温未变。
