Smith R E, Van Eldik L J
Infect Immun. 1978 Nov;22(2):452-61. doi: 10.1128/iai.22.2.452-461.1978.
Infection of chickens with a myeloblastosis-associated virus which induced a high incidence of osteopetrosis was accompanied by immunosuppression. The immunosuppression was manifested in the following ways. The weight of the bursa, spleen, and thymus was depressed in infected chickens. Infected animals had a diminished capacity to form hemolytic plaques in a direct assay. Spleen cells from osteopetrotic animals did not respond to phytohemagglutinin, and the spleen and bursa had a decreased proportion of cells possessing surface immunoglobulin. Osteopetrotic animals failed to show an age-dependent increase in the proportion of cells demonstrating surface immunoglobulin that was observed in normal animals. However, several individual chickens with heavy osteopetrosis responded to antigenic stimulation in a normal fashion, indicating that although immunosuppression usually accompanies avian osteopetrosis, it may not contribute directly to abnormal bone proliferation.
感染成髓细胞增多症相关病毒并引发高发性骨硬化症的鸡会出现免疫抑制。这种免疫抑制表现如下：感染鸡的法氏囊、脾脏和胸腺重量减轻。在直接检测中，感染动物形成溶血斑的能力降低。患骨硬化症动物的脾细胞对植物血凝素无反应，且脾脏和法氏囊中具有表面免疫球蛋白的细胞比例降低。患骨硬化症的动物未呈现出正常动物中随年龄增长而出现的具有表面免疫球蛋白的细胞比例增加的现象。然而，几只患有严重骨硬化症的个体鸡以正常方式对抗抗原刺激，这表明尽管免疫抑制通常伴随禽类骨硬化症，但它可能并非直接导致异常骨增殖的原因。
