Bumb A, Brechbiel M W, Choyke P L, Fugger L, Eggeman A, Prabhakaran D, Hutchinson J, Dobson P J
Oxford University Begbroke Science Park, Sandy Lane, Kidlington, Oxon OX5 1PF, UK. Email:
Nanotechnology. 2008 Aug 20;19(33):335601. doi: 10.1088/0957-4484/19/33/335601.
Ultra-small superparamagnetic iron oxide nanoparticles (SPIOs) were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (~2nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications as MR contrast agents, biosensors, DNA capturing, bioseparation and enzyme immobilization.
通过氯化铁盐与氨的共沉淀法合成了超小超顺磁性氧化铁纳米颗粒（SPIOs），然后用约2纳米厚的二氧化硅层进行包裹。对这些颗粒的尺寸、衍射图案、表面电荷和磁性进行了表征。这种快速且经济的合成方法有许多工业应用；然而，这种二氧化硅包覆的颗粒已被优化用于医学应用，如磁共振造影剂、生物传感器、DNA捕获、生物分离和酶固定化。
