Lee Paul P, Cunningham William E, Nakazono Terry T, Hays Ron D
RAND, Health Sciences Program, Santa Monica, CA, USA.
Am J Ophthalmol. 2009 Nov;148(5):804-808.e1. doi: 10.1016/j.ajo.2009.06.021. Epub 2009 Aug 26.
To study the associations of eye diseases and visual symptoms with the most widely used health-related quality-of-life (HRQOL) generic profile measure.
HRQOL was assessed using the short form-36 (SF-36) version 1 survey administered to a sample of patients receiving care provided by a physician group practice association.
Eye diseases, ocular symptoms, and general health were assessed in a sample of patients from 48 physician groups. A total of 18,480 surveys were mailed out and 7,093 returned; 5,021 of these had complete data. Multiple linear regression models were used to examine the decrements in self-reported physical and mental health associated with eye diseases and symptoms, including trouble seeing and blurred vision.
Nine percent of the respondents had cataracts, 2% had age-related macular degeneration, 2% glaucoma, 8% blurred vision, and 13% trouble seeing. Trouble seeing and blurred vision both had statistically unique associations with worse scores on the SF-36 mental health summary score. Only trouble seeing had a significant association with the SF-36 physical health summary score. While these ocular symptoms were significantly associated with SF-36 scores, having an eye disease (cataracts, glaucoma, and macular degeneration) was not, after adjusting for other variables in the model.
Our results suggest an important link between visual symptoms and general HRQOL. The study extends the findings of prior research to show that both trouble seeing and blurred vision have independent, measurable associations with HRQOL, while the presence of specific eye diseases may not.
研究眼部疾病和视觉症状与应用最为广泛的健康相关生活质量(HRQOL)通用量表之间的关联。
采用简短健康调查问卷(SF-36)第1版对一组接受医师团体执业协会医疗服务的患者样本进行HRQOL评估。
对来自48个医师团体的患者样本进行眼部疾病、眼部症状及总体健康状况评估。共寄出18480份调查问卷,回收7093份;其中5021份有完整数据。采用多元线性回归模型研究与眼部疾病及症状(包括视物困难和视力模糊)相关的自我报告的身心健康状况下降情况。
9%的受访者患有白内障,2%患有年龄相关性黄斑变性,2%患有青光眼,8%有视力模糊症状,13%视物困难。视物困难和视力模糊均与SF-36心理健康汇总评分较差在统计学上存在独特关联。仅视物困难与SF-36身体健康汇总评分存在显著关联。虽然这些眼部症状与SF-36评分显著相关,但在对模型中的其他变量进行调整后,患有眼部疾病(白内障、青光眼和黄斑变性)与评分无关。
我们的结果表明视觉症状与总体HRQOL之间存在重要联系。该研究扩展了先前研究的结果,表明视物困难和视力模糊均与HRQOL存在独立、可测量的关联,而特定眼部疾病的存在可能并非如此。