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Epigenetic dysregulation in cancer.癌症中的表观遗传失调。
Am J Pathol. 2009 Oct;175(4):1353-61. doi: 10.2353/ajpath.2009.081142. Epub 2009 Aug 28.
2
Epigenome dysregulation in cholangiocarcinoma.胆管癌中的表观基因组失调。
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1423-1434. doi: 10.1016/j.bbadis.2017.06.014. Epub 2017 Jun 20.
3
Epigenetic inhibitors and their role in cancer therapy.表观遗传抑制剂及其在癌症治疗中的作用。
Int Rev Cell Mol Biol. 2023;380:211-251. doi: 10.1016/bs.ircmb.2023.04.005. Epub 2023 Aug 1.
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Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications.胰腺癌中表观遗传调控因子的改变及其临床意义
Int J Mol Sci. 2016 Dec 19;17(12):2138. doi: 10.3390/ijms17122138.
5
Epigenetic mechanisms in gastric cancer.胃癌中的表观遗传机制。
Epigenomics. 2012 Jun;4(3):279-94. doi: 10.2217/epi.12.22.
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Interplay between different epigenetic modifications and mechanisms.不同表观遗传修饰和机制之间的相互作用。
Adv Genet. 2010;70:101-41. doi: 10.1016/B978-0-12-380866-0.60005-8.
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Epigenetic modifications in gastric cancer: Focus on DNA methylation.胃癌中的表观遗传修饰：关注 DNA 甲基化。
Gene. 2020 Jun 5;742:144577. doi: 10.1016/j.gene.2020.144577. Epub 2020 Mar 18.
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DNA methylation and chromatin modifiers in colorectal cancer.结直肠癌中的 DNA 甲基化和染色质修饰物。
Mol Aspects Med. 2019 Oct;69:73-92. doi: 10.1016/j.mam.2019.04.002. Epub 2019 Apr 30.
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Cancer epigenetics: from mechanism to therapy.癌症表观遗传学：从机制到治疗。
Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
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Involvement of noncoding RNAs in epigenetic modifications of esophageal cancer.非编码 RNA 在食管癌表观遗传修饰中的作用。
Biomed Pharmacother. 2019 Sep;117:109192. doi: 10.1016/j.biopha.2019.109192. Epub 2019 Jul 11.
引用本文的文献
1
ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer.ACTL6A缺失在结直肠癌中诱导KLF4介导的抗肿瘤作用。
Cell Death Dis. 2025 Aug 28;16(1):653. doi: 10.1038/s41419-025-07946-w.
2
Investigating the binding mechanism of AML inhibitors based on panobinostat with HDAC3 proteins using Gaussian accelerated molecular dynamics.利用高斯加速分子动力学研究基于帕比司他的急性髓系白血病抑制剂与组蛋白去乙酰化酶3蛋白的结合机制。
RSC Adv. 2025 Jul 23;15(32):26240-26252. doi: 10.1039/d5ra01129a. eCollection 2025 Jul 21.
3
Current advances and future directions in targeting histone demethylases for cancer therapy.靶向组蛋白去甲基化酶用于癌症治疗的当前进展与未来方向。
Mol Cells. 2025 Mar;48(3):100192. doi: 10.1016/j.mocell.2025.100192. Epub 2025 Feb 10.
4
Transposable element 5mC methylation state of blood cells predicts age and disease.血细胞的转座元件5mC甲基化状态可预测年龄和疾病。
Nat Aging. 2025 Feb;5(2):193-204. doi: 10.1038/s43587-024-00757-2. Epub 2024 Nov 27.
5
Chromosomal instability as a driver of cancer progression.染色体不稳定性作为癌症进展的驱动因素。
Nat Rev Genet. 2025 Jan;26(1):31-46. doi: 10.1038/s41576-024-00761-7. Epub 2024 Jul 29.
6
Over-expression of mir-181a-3p in serum of breast cancer patients as diagnostic biomarker.乳腺癌患者血清中 mir-181a-3p 的过表达可作为诊断生物标志物。
Mol Biol Rep. 2024 Feb 27;51(1):372. doi: 10.1007/s11033-024-09272-4.
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Current and future therapeutic strategies for high-grade gliomas leveraging the interplay between epigenetic regulators and kinase signaling networks.利用表观遗传调控因子和激酶信号网络之间的相互作用，针对高级别神经胶质瘤的当前和未来治疗策略。
J Exp Clin Cancer Res. 2024 Jan 5;43(1):12. doi: 10.1186/s13046-023-02923-7.
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Visualization of breast cancer-related protein synthesis from the perspective of bibliometric analysis.从文献计量分析的角度看乳腺癌相关蛋白的合成。
Eur J Med Res. 2023 Oct 27;28(1):461. doi: 10.1186/s40001-023-01364-4.
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A genomic enhancer signature associates with hepatocellular carcinoma prognosis.一种基因组增强子特征与肝细胞癌预后相关。
JHEP Rep. 2023 Feb 26;5(6):100715. doi: 10.1016/j.jhepr.2023.100715. eCollection 2023 Jun.
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Targeting redox regulation and autophagy systems in cancer stem cells.靶向肿瘤干细胞中的氧化还原调控和自噬系统。
Clin Exp Med. 2023 Sep;23(5):1405-1423. doi: 10.1007/s10238-022-00955-5. Epub 2022 Dec 6.
本文引用的文献
1
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells.大的组蛋白H3赖氨酸9二甲基化染色质结构域区分分化细胞与胚胎干细胞。
Nat Genet. 2009 Feb;41(2):246-50. doi: 10.1038/ng.297. Epub 2009 Jan 18.
2
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.微小RNA - 101的基因组缺失导致癌症中组蛋白甲基转移酶EZH2的过表达。
Science. 2008 Dec 12;322(5908):1695-9. doi: 10.1126/science.1165395. Epub 2008 Nov 13.
3
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.H3K79甲基化谱定义了小鼠和人类MLL-AF4白血病。
Cancer Cell. 2008 Nov 4;14(5):355-68. doi: 10.1016/j.ccr.2008.10.001.
4
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.组织蛋白酶L在小鼠胚胎干细胞分化过程中对组蛋白H3进行蛋白水解加工。
Cell. 2008 Oct 17;135(2):284-94. doi: 10.1016/j.cell.2008.09.055.
5
A model for transmission of the H3K27me3 epigenetic mark.一种H3K27me3表观遗传标记的传递模型。
Nat Cell Biol. 2008 Nov;10(11):1291-300. doi: 10.1038/ncb1787. Epub 2008 Oct 19.
6
Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.黏膜相关淋巴组织淋巴瘤：新型易位，包括ODZ2、JMJD2C和CNN3的重排。
Clin Cancer Res. 2008 Oct 15;14(20):6426-31. doi: 10.1158/1078-0432.CCR-08-0702.
7
The PHD fingers of MLL block MLL fusion protein-mediated transformation.MLL的PHD结构域可阻断MLL融合蛋白介导的转化。
Blood. 2008 Dec 1;112(12):4690-3. doi: 10.1182/blood-2008-01-134056. Epub 2008 Sep 16.
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Is there a code embedded in proteins that is based on post-translational modifications?是否存在一种基于翻译后修饰的蛋白质中嵌入的编码？
Nat Rev Mol Cell Biol. 2008 Oct;9(10):815-20. doi: 10.1038/nrm2502. Epub 2008 Sep 11.
9
The ING gene family in the regulation of cell growth and tumorigenesis.ING基因家族在细胞生长和肿瘤发生调控中的作用
J Cell Physiol. 2009 Jan;218(1):45-57. doi: 10.1002/jcp.21583.
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PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.人类疾病中的PHD指蛋白：因错误解读表观遗传标记而引发的疾病
Mutat Res. 2008 Dec 1;647(1-2):3-12. doi: 10.1016/j.mrfmmm.2008.07.004. Epub 2008 Jul 17.
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