Kim Sae-Hoon, Lee Sang-Min, Park Heung-Woo, Cho Sang-Heon, Min Kyung-Up, Kim You-Young, Chang Yoon-Seok
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Korean J Intern Med. 2009 Sep;24(3):279-82. doi: 10.3904/kjim.2009.24.3.279. Epub 2009 Aug 26.
A 56-year-old man who had suffered from seasonal rhinitis in spring and autumn experienced recurrent generalized urticaria and an oral burning sensation after eating several cooked herbs for 3 months. A skin-prick test showed positive responses to various pollens, celery, Chinese bellflower, and arrowroot. The Chinese bellflower-specific IgE ELISA OD value was 1.547. Oral challenge with unprocessed raw Chinese bellflower root provoked oral burning sensation, eyelid swelling, generalized urticaria, and hypotension. In an ELISA inhibition test, IgE binding to Chinese bellflower was significantly inhibited by Chinese bellflower, mugwort, and birch pollen extract. SDS-PAGE and immunoblot assay revealed nine IgE-binding components, and common protein bands were detected in the range of 40~55 kDa (Chinese bellflower-mugwort-birch) and 14 kDa (Chinese bellflower-birch). Chinese bellflower root can cause anaphylaxis and may have cross-reactivity with mugwort and birch.
一名56岁男性，春秋季患有季节性鼻炎，在食用几种草药3个月后出现反复全身性荨麻疹和口腔烧灼感。皮肤点刺试验显示对多种花粉、芹菜、桔梗和竹芋呈阳性反应。桔梗特异性IgE ELISA OD值为1.547。用未加工的生桔梗根进行口服激发试验，引发口腔烧灼感、眼睑肿胀、全身性荨麻疹和低血压。在ELISA抑制试验中，桔梗、艾蒿和桦树花粉提取物可显著抑制IgE与桔梗的结合。SDS-PAGE和免疫印迹分析显示有9种IgE结合成分，在40~55 kDa（桔梗-艾蒿-桦树）和14 kDa（桔梗-桦树）范围内检测到共同蛋白条带。桔梗根可引起过敏反应，可能与艾蒿和桦树有交叉反应。
