Lopes José Daniel, Mariano Mario
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
An Acad Bras Cienc. 2009 Sep;81(3):489-96. doi: 10.1590/s0001-37652009000300013.
Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse characteristics of mammalian cells, some of them, such as B-1 cells, are still poorly understood. Here we report the results obtained in our laboratory on these cells in the last 10 years. After showing that B-1 cells could be cultured and amplified in vitro, a series of experiments were performed with these cells. They showed that B1 cells reside mostly in the peritoneal and pleural cavities, migrate to distant inflammatory foci, coalesce to form giant cells and participate in granuloma formation, both in vitro and in vivo. They are also able to present antigens to immunologically responsive cells and are endowed with regulatory properties. Further, we have also shown that these cells facilitate different types of infection as well as tumor growth and spreading. These data are presently reviewed pointing to a pivotal role that these cells may play in innate and acquired immunity.
对细胞的起源、特性、功能和命运进行表征是理解生理和病理现象的一项基本任务。尽管已经积累了大量关于哺乳动物细胞各种特征的知识，但其中一些细胞，如B-1细胞，仍然了解甚少。在此，我们报告过去10年在我们实验室对这些细胞所取得的研究结果。在证明B-1细胞能够在体外培养和扩增之后，我们用这些细胞进行了一系列实验。结果表明，B-1细胞主要存在于腹膜腔和胸膜腔中，能够迁移至远处的炎症病灶，聚集形成巨细胞，并在体外和体内参与肉芽肿的形成。它们还能够将抗原呈递给免疫反应细胞，并具有调节特性。此外，我们还表明，这些细胞促进不同类型的感染以及肿瘤的生长和扩散。目前对这些数据进行综述，指出这些细胞可能在先天免疫和获得性免疫中发挥关键作用。
