Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
J Mol Cell Biol. 2009 Dec;1(2):66-8. doi: 10.1093/jmcb/mjp016. Epub 2009 Sep 2.
T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and RORgammat and RORalpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and by maintaining RORalpha and RORgammat expression, shedding new lights on current clinical modulation of Th17 cell function in inflammatory diseases.
辅助性 T 细胞 17（Th17）细胞是最近鉴定出的一类能够调控组织炎症的 T 细胞亚群，RORγt 和 RORα 已被证实为介导 Th17 细胞生成的 Th17 特异性转录因子。一项关于 Batf 缺陷型小鼠的新研究表明，这种 AP-1 家族转录因子通过结合 Th17 相关基因启动子并维持 RORα 和 RORγt 的表达，也调节 Th17 细胞分化，这为目前在炎症性疾病中对 Th17 细胞功能的临床调节提供了新的思路。
