Su H J, Wu P C, Chen H L, Lee F C, Lin L L
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng Li Road, Tainan, Taiwan 70428, Republic of China.
Environ Res. 2001 Feb;85(2):135-44. doi: 10.1006/enrs.2000.4113.
This study was undertaken to examine the seasonal variations of domestic Der p 1, Der p 2, and endotoxin on mattress and airborne fungal concentrations in homes of asthmatic and nonasthmatic children in southern Taiwan, where temperature and relative humidity are usually high throughout the year. A group of asthmatic children (10-12 years old) were selected randomly based on a citywide questionnaire survey. The nonasthmatic children were chosen to be in the comparison group by matching in age, gender, and proximity of residence. Environmental sampling of domestic microbes was conducted once a month for a year. Twelve calendar months were grouped into spring, summer, fall, and winter according to weather data (mainly average temperature and humidity) from the Central Weather Bureau. Dust samples from a child's mattress and airborne samples from a child's bedroom were collected and analyzed for allergens of Der p 1 and Der p 2, endotoxin, and fungi respectively. Results show that about 65% of children's mattresses in our region have Der p 1 levels greater than 2 microg/g. It is also apparent that most airborne fungal concentrations found in homes of either asthmatic or nonasthmatic children are higher than the recommended levels of concern. The predominant genera are Cladosporium, Aspergillus, Penicillium, Alternaria, and yeast. In addition, seasonal effects seem to be a critical factor for the concentrations and distributions of domestic endotoxin in these study homes. The implication of long-term exposure to these high levels of environmental microbes and how their effects vary with seasons remain to be further characterized.
本研究旨在调查台湾南部哮喘和非哮喘儿童家中床垫上的屋尘螨变应原Der p 1、Der p 2和内毒素以及空气中真菌浓度的季节性变化，该地区全年温度和相对湿度通常较高。通过全市范围的问卷调查随机选取一组10 - 12岁的哮喘儿童。非哮喘儿童通过年龄、性别和居住距离匹配选为对照组。一年内每月对家庭微生物进行一次环境采样。根据中央气象局的气象数据（主要是平均温度和湿度），将十二个日历月分为春、夏、秋、冬四季。分别收集儿童床垫上的灰尘样本和儿童卧室中的空气样本，分析其中Der p 1和Der p 2的过敏原、内毒素和真菌。结果显示，本地区约65%儿童床垫中的Der p 1水平高于2微克/克。同样明显的是，哮喘或非哮喘儿童家中发现的大多数空气中真菌浓度高于推荐的关注水平。优势菌属为枝孢属、曲霉属、青霉属、链格孢属和酵母菌。此外，季节效应似乎是这些研究家庭中室内内毒素浓度和分布的关键因素。长期暴露于这些高水平环境微生物的影响以及其影响如何随季节变化仍有待进一步明确。
