Burger H, Belman A L, Grimson R, Kaell A, Flaherty K, Gulla J, Gibbs R A, Nguyun P N, Weiser B
Department of Medicine, State University of New York, Stony Brook 11794.
Lancet. 1990 Jul 21;336(8708):134-6. doi: 10.1016/0140-6736(90)91657-v.
The incubation period of human immunodeficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4(+)-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.
对一个五口之家进行了研究，以探讨1型人类免疫缺陷病毒（HIV-1）感染的潜伏期，在这个家庭中，一名索引病例发生了垂直传播和异性传播。该调查记录了一位母亲和她女儿的潜伏期超过12年；尽管两人都没有症状，但都确实受到感染，且CD4（+）淋巴细胞计数非常低。该研究证实了一小部分受感染个体潜伏期超过10年的预测。它提供了证据表明，预计人群中会出现垂直感染HIV-1的青少年。
