Cavallaro Roberto, Anselmetti Simona, Poletti Sara, Bechi Margherita, Ermoli Elena, Cocchi Federica, Stratta Paolo, Vita Antonio, Rossi Alessandro, Smeraldi Enrico
Department of Clinical Neurosciences, San Raffaele Universitary Scientific Institute Hospital, Vita-Salute San Raffaele University, Milano, Italy.
Psychiatry Res. 2009 Oct 30;169(3):191-6. doi: 10.1016/j.psychres.2008.06.027. Epub 2009 Sep 9.
Cognitive dysfunction is a chronically disabling feature of schizophrenia, associated with limits in obtaining rehabilitation improvements. The purpose of this study is to assess the effectiveness of intensive computer-aided cognitive remediation treatment (CRT) added to a standard rehabilitation treatment (SRT), in enhancing neuropsychological performances and daily functioning in patients with schizophrenia. A 12-week, randomized, controlled, single-blind trial of neurocognitive remediation was carried out on 86 patients with clinically stabilized DSM-IV schizophrenia. Patients were assessed on cognitive and daily functioning before and after either CRT or placebo training that had been added to their SRT. After 3 months the repeated measure ANOVA showed a significant time x treatment interaction for executive function and attention performances and in daily functioning assessment in favour of patients in the SRT+CRT treatment. Results confirmed that cognitive remediation added to the SRT of schizophrenia enhanced its neuropsychological effects and increased the effects of a long-term rehabilitation programme in terms of functional outcomes.
认知功能障碍是精神分裂症的一种慢性致残特征，与康复改善受限有关。本研究的目的是评估在标准康复治疗（SRT）基础上增加强化计算机辅助认知康复治疗（CRT），对提高精神分裂症患者神经心理表现和日常功能的有效性。对86例临床症状稳定的DSM-IV精神分裂症患者进行了一项为期12周的随机对照单盲神经认知康复试验。在患者接受添加到SRT中的CRT或安慰剂训练前后，对其认知和日常功能进行评估。3个月后，重复测量方差分析显示，在执行功能、注意力表现和日常功能评估方面，时间×治疗存在显著交互作用，表明SRT+CRT治疗组患者更具优势。结果证实，在精神分裂症的SRT基础上增加认知康复治疗可增强其神经心理效应，并在功能结局方面提高长期康复计划的效果。
