Srivastava S, Natu S M, Gupta A, Pal K A, Singh U, Agarwal G G, Singh Uma, Goel M M, Srivastava A N
Department of Pathology, Lucknow University, India.
Indian J Cancer. 2009 Oct-Dec;46(4):297-302. doi: 10.4103/0019-509X.55549.
Free radical Injury is associated with cancer, but how the extent of oxidative stress correlates with the FIGO (International Federation of Gynecology and Obstetrics) stage in Carcinoma Cervix (Ca Cx), and its significance as a prognostic marker, is not clear and needs an in-depth study.
To correlate the blood levels of Lipid Peroxidation (LPO), Reduced Glutathione (GSH), Superoxide Dismutase (SOD), and Vitamin A and E levels with the clinical stage in Ca Cx.
This is a Prospective Case Control Study.
LPO, SOD, reduced GSH were estimated by Bio Chemical Assays and Vitamins by High Performance Liquid Chromatography (HPLC).
The cases and controls were compared using One Way ANOVA and different stages over different time periods were individually compared by Repeated Measure Analysis of Variance.
The results indicated a statistically significant increase of LPO vis-a-vis the FIGO stage of Ca Cx and control, while the antioxidant status as depicted by GSH and SOD decreased. Vitamin A and E levels were significantly lower in cancer cases as compared to the control.
Increased LPO and reduced antioxidant levels may be taken as associated predictive markers, thus suggesting that Ca Cx cases should get nutritive supplements to contain the blood LPO level and maintain a positive balance of antioxidants for a better outcome in terms of delayed recurrence and better Quality of Life (QOL).
自由基损伤与癌症相关，但氧化应激程度如何与宫颈癌（Ca Cx）的国际妇产科联盟（FIGO）分期相关，以及其作为预后标志物的意义尚不清楚，需要深入研究。
将脂质过氧化（LPO）、还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）的血液水平以及维生素A和E水平与Ca Cx的临床分期相关联。
这是一项前瞻性病例对照研究。
通过生化测定法估算LPO、SOD、还原型GSH，并通过高效液相色谱法（HPLC）测定维生素。
使用单因素方差分析比较病例组和对照组，并通过重复测量方差分析分别比较不同时间段的不同分期。
结果表明，相对于Ca Cx的FIGO分期和对照组，LPO有统计学意义的升高，而GSH和SOD所代表的抗氧化状态降低。与对照组相比，癌症病例中的维生素A和E水平显著较低。
LPO升高和抗氧化水平降低可被视为相关的预测标志物，因此表明Ca Cx病例应补充营养以控制血液LPO水平，并维持抗氧化剂的正平衡，以期在延迟复发和提高生活质量（QOL）方面获得更好的结果。
