McConnell Beth B, Yang Vincent W
Curr Colorectal Cancer Rep. 2009 Apr 1;5(2):69-74. doi: 10.1007/s11888-009-0011-z.
Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.
慢性炎症性疾病通常与患癌风险增加有关。炎症与癌症之间联系的一个典型例子是炎症性肠病（IBD）患者患结直肠癌的风险增加。在本综述中，我们讨论了IBD中促进结直肠癌的方面，并强调了导致癌症风险的关键分子介质。此外，我们报告了在确定可能有效阻断IBD相关炎症向癌症进展的分子靶点方面的进展。
