炎症在结直肠癌发病机制中的作用
The Role of Inflammation in the Pathogenesis of Colorectal Cancer.
作者信息
McConnell Beth B, Yang Vincent W
出版信息
Curr Colorectal Cancer Rep. 2009 Apr 1;5(2):69-74. doi: 10.1007/s11888-009-0011-z.
Abstract
Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.
摘要
慢性炎症性疾病通常与患癌风险增加有关。炎症与癌症之间联系的一个典型例子是炎症性肠病（IBD）患者患结直肠癌的风险增加。在本综述中，我们讨论了IBD中促进结直肠癌的方面，并强调了导致癌症风险的关键分子介质。此外，我们报告了在确定可能有效阻断IBD相关炎症向癌症进展的分子靶点方面的进展。
相似文献
1
The Role of Inflammation in the Pathogenesis of Colorectal Cancer.炎症在结直肠癌发病机制中的作用
Curr Colorectal Cancer Rep. 2009 Apr 1;5(2):69-74. doi: 10.1007/s11888-009-0011-z.
2
Molecular pathways underlying IBD-associated colorectal neoplasia: therapeutic implications.炎症性肠病相关结直肠肿瘤的分子通路：治疗意义。
Am J Gastroenterol. 2011 Apr;106(4):719-30. doi: 10.1038/ajg.2011.51. Epub 2011 Mar 8.
3
Inflammation and colorectal cancer.炎症与结直肠癌。
Curr Opin Pharmacol. 2009 Aug;9(4):405-10. doi: 10.1016/j.coph.2009.06.006. Epub 2009 Jul 7.
4
The Impact of Inflammatory Bowel Disease in Canada 2018: Extra-intestinal Diseases in IBD.2018年加拿大炎症性肠病的影响：炎症性肠病的肠外疾病
J Can Assoc Gastroenterol. 2019 Feb;2(Suppl 1):S73-S80. doi: 10.1093/jcag/gwy053. Epub 2018 Nov 2.
5
Colorectal Cancer in Inflammatory Bowel Disease: A Review of the Role of Gut Microbiota and Bacterial Biofilms in Disease Pathogenesis.炎症性肠病中的结直肠癌：肠道微生物群和细菌生物膜在疾病发病机制中的作用综述。
J Crohns Colitis. 2024 Oct 15;18(10):1713-1725. doi: 10.1093/ecco-jcc/jjae061.
6
Dysplastic lesions in inflammatory bowel disease: molecular pathogenesis to morphology.炎症性肠病中的发育异常病变：从分子发病机制到形态学。
Arch Pathol Lab Med. 2013 Mar;137(3):338-50. doi: 10.5858/arpa.2012-0086-RA.
7
Comparative analysis of single-cell transcriptome reveals heterogeneity and commonality in the immune microenvironment of colorectal cancer and inflammatory bowel disease.单细胞转录组比较分析揭示结直肠癌和炎症性肠病免疫微环境的异质性和共性。
Front Immunol. 2024 Mar 11;15:1356075. doi: 10.3389/fimmu.2024.1356075. eCollection 2024.
8
From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies.从炎症到炎症性肠病相关的结直肠癌：发病机制和当前治疗的影响。
Dig Liver Dis. 2021 May;53(5):558-565. doi: 10.1016/j.dld.2021.01.012. Epub 2021 Feb 1.
9
Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links.炎症性肠病、结直肠癌与2型糖尿病：它们之间的联系。
BBA Clin. 2015 Nov 5;5:16-24. doi: 10.1016/j.bbacli.2015.11.002. eCollection 2016 Jun.
10
Clinicopathological and Molecular Specificities of Inflammatory Bowel Disease-Related Colorectal Neoplastic Lesions: The Role of Inflammation.炎症性肠病相关结直肠肿瘤病变的临床病理和分子特征：炎症的作用。
J Crohns Colitis. 2018 Nov 28;12(12):1486-1498. doi: 10.1093/ecco-jcc/jjy132.
引用本文的文献
1
Potential therapeutic effects of crocin.藏红花素的潜在治疗作用。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7395-7420. doi: 10.1007/s00210-024-03131-6. Epub 2024 May 17.
2
Molecular Mechanisms Associated with the Inhibitory Role of Long Chain n-3 PUFA in Colorectal Cancer.长链 n-3PUFA 抑制结直肠癌作用的分子机制。
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241243024. doi: 10.1177/15347354241243024.
3
Predictive modeling algorithms for liver metastasis in colorectal cancer: A systematic review of the current literature.结直肠癌肝转移的预测建模算法：当前文献的系统评价
Ann Hepatobiliary Pancreat Surg. 2024 Feb 29;28(1):14-24. doi: 10.14701/ahbps.23-078. Epub 2023 Dec 22.
4
Synergistic anticancer effects of curcumin and crocin on human colorectal cancer cells.姜黄素与藏红花素对人结肠癌细胞的协同抗癌作用。
Mol Biol Rep. 2022 Sep;49(9):8741-8752. doi: 10.1007/s11033-022-07719-0. Epub 2022 Aug 21.
5
Chemoprevention of Colitis-Associated Dysplasia or Cancer in Inflammatory Bowel Disease.炎症性肠病中化学预防结肠炎相关异型增生或癌症。
Gut Liver. 2022 Nov 15;16(6):840-848. doi: 10.5009/gnl210479. Epub 2022 Jun 7.
6
ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance.ABC 转运蛋白与癌症的特征：超越多药耐药性的癌症侵袭性作用。
Cancer Biol Med. 2020 May 15;17(2):253-269. doi: 10.20892/j.issn.2095-3941.2019.0284.
7
Role of crocin in several cancer cell lines: An updated review.西红花苷在几种癌细胞系中的作用：最新综述。
Iran J Basic Med Sci. 2020 Jan;23(1):3-12. doi: 10.22038/IJBMS.2019.37821.8995.
8
Evaluation of SEPP1 and Selenoprotein S Gene Polymorphisms (rs7579 and rs34713741) in Relation to Colorectal Cancer Susceptibility in Subset of Iranian Population: A Case-control Study.伊朗人群亚组中SEPP1和硒蛋白S基因多态性（rs7579和rs34713741）与结直肠癌易感性关系的评估：一项病例对照研究
Adv Biomed Res. 2019 Jul 25;8:47. doi: 10.4103/abr.abr_249_18. eCollection 2019.
9
Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer.Chemerin 血浆浓度与结直肠癌风险的关联。
JAMA Netw Open. 2019 Mar 1;2(3):e190896. doi: 10.1001/jamanetworkopen.2019.0896.
10
Colorectal cancer in inflammatory bowel disease: review of the evidence.炎症性肠病相关结直肠癌：文献回顾。
Tech Coloproctol. 2019 Jan;23(1):3-13. doi: 10.1007/s10151-019-1926-2. Epub 2019 Jan 30.
本文引用的文献
1
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.白细胞介素10、肌动蛋白相关蛋白2及多个其他基因座中的序列变异会导致溃疡性结肠炎易感性。
Nat Genet. 2008 Nov;40(11):1319-23. doi: 10.1038/ng.221. Epub 2008 Oct 5.
2
Cancer-related inflammation.癌症相关炎症
Nature. 2008 Jul 24;454(7203):436-44. doi: 10.1038/nature07205.
3
NF-kappaB and cancer-identifying targets and mechanisms.核因子-κB与癌症识别靶点及机制
Curr Opin Genet Dev. 2008 Feb;18(1):19-26. doi: 10.1016/j.gde.2008.01.020. Epub 2008 Apr 24.
4
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.溃疡性结肠炎的遗传决定因素包括ECM1基因座和与克罗恩病相关的五个基因座。
Nat Genet. 2008 Jun;40(6):710-2. doi: 10.1038/ng.145. Epub 2008 Apr 27.
5
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.在小鼠中阻断肿瘤坏死因子-α可减少与慢性结肠炎相关的结直肠癌发生。
J Clin Invest. 2008 Feb;118(2):560-70. doi: 10.1172/JCI32453.
6
Colitis and cancer: a tale of inflammatory cells and their cytokines.结肠炎与癌症：炎症细胞及其细胞因子的故事
J Clin Invest. 2008 Feb;118(2):464-7. doi: 10.1172/JCI34831.
7
Immunopathogenesis of inflammatory bowel disease.炎症性肠病的免疫发病机制
World J Gastroenterol. 2008 Jan 21;14(3):390-400. doi: 10.3748/wjg.14.390.
8
Polymorphisms in Toll-like receptor genes and risk of cancer.Toll样受体基因多态性与癌症风险
Oncogene. 2008 Jan 7;27(2):244-52. doi: 10.1038/sj.onc.1210912.
9
Role of Toll-like receptors in gastrointestinal malignancies.Toll样受体在胃肠道恶性肿瘤中的作用。
Oncogene. 2008 Jan 7;27(2):234-43. doi: 10.1038/sj.onc.1210908.
10
Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.Toll样受体4促进结肠炎相关结直肠癌的发展。
Gastroenterology. 2007 Dec;133(6):1869-81. doi: 10.1053/j.gastro.2007.09.008. Epub 2007 Sep 14.
Zotero 插件