Li Linlin, Victoria Joseph, Kapoor Amit, Blinkova Olga, Wang Chunlin, Babrzadeh Farbod, Mason Carl J, Pandey Prativa, Triki Hinda, Bahri Olfa, Oderinde Bamidele Soji, Baba Marycelin Mandu, Bukbuk David Nadeba, Besser John M, Bartkus Joanne M, Delwart Eric L
Blood Systems Research Institute, San Francisco, CA 94118, USA.
J Virol. 2009 Nov;83(22):12002-6. doi: 10.1128/JVI.01241-09. Epub 2009 Sep 16.
A novel picornavirus genome was sequenced, showing 42.6%, 35.2%, and 44.6% of deduced amino acid identities corresponding to the P1, P2, and P3 regions, respectively, of the Aichi virus. Divergent strains of this new virus, which we named salivirus, were detected in 18 stool samples from Nigeria, Tunisia, Nepal, and the United States. A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056). Viruses with approximately 90% nucleotide similarity, named klassevirus, were also recently reported in three cases of unexplained diarrhea from the United States and Australia and in sewage from Spain, reflecting a global distribution and supporting a pathogenic role for this new group of picornaviruses.
对一种新型微小核糖核酸病毒基因组进行了测序，结果显示，其推导的氨基酸序列与爱知病毒的P1、P2和P3区域的一致性分别为42.6%、35.2%和44.6%。在来自尼日利亚、突尼斯、尼泊尔和美国的18份粪便样本中检测到了这种我们命名为唾液病毒的新病毒的不同毒株。在尼泊尔，病毒排泄与不明原因的肠胃炎病例之间存在统计学关联（P = 0.0056）。最近在美国和澳大利亚的3例不明原因腹泻病例以及西班牙的污水中也报告了核苷酸相似度约为90%的病毒，即类病毒，这反映了其全球分布情况，并支持了这一新组微小核糖核酸病毒的致病作用。
