Zhang Minyi, Li Qiushuang, Wu Fei, Ou Zejin, Li Yongzhi, You Fangfei, Chen Qing
Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Pathogens. 2021 May 28;10(6):661. doi: 10.3390/pathogens10060661.
is a novel member of the family . A single species, , is currently described. However, there is limited information on the identification of to date, and thereby the circulation of is not fully understood. Thus, the objective of this study was to investigate the prevalence, genomic characteristics, and evolution of rat hunnivirus in southern China. A total of 404 fecal samples were subjected to detection of from urban rats ( and ) using PCR assay based on specific primers targeted to partial 3D regions, with the prevalence of 17.8% in and 15.6% in . An almost full-length rat hunnivirus sequence (RatHuV/YY12/CHN) and the genome structure were acquired in the present study. Phylogenetic analysis of the P1 coding regions suggested the RatHuV/YY12/CHN sequence was found to be within the genotype of . The negative selection was further identified based on analysis of non-synonymous to synonymous substitution rates. The present findings suggest that hunniviruses are common in urban rats. Further research is needed for increased surveillance and awareness of potential risks to human health.
是该病毒家族的一个新成员。目前已描述了一个单一物种，即。然而，迄今为止关于的鉴定信息有限，因此其传播情况尚未完全了解。因此，本研究的目的是调查中国南方大鼠汉尼病毒的流行情况、基因组特征和进化。使用基于针对部分3D区域的特异性引物的PCR检测法，对来自城市大鼠（和）的404份粪便样本进行了检测，其中的流行率在中为17.8%，在中为15.6%。在本研究中获得了一个几乎全长的大鼠汉尼病毒序列（RatHuV/YY12/CHN）及其基因组结构。对P1编码区的系统发育分析表明，RatHuV/YY12/CHN序列属于的基因型。基于非同义替换率与同义替换率的分析进一步确定了负选择。目前的研究结果表明，汉尼病毒在城市大鼠中很常见。需要进一步研究以加强监测并提高对人类健康潜在风险的认识。
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