Ablon Glynis
Ablon Skin Institute, Los Angeles, California, USA.
Photomed Laser Surg. 2010 Feb;28(1):141-6. doi: 10.1089/pho.2009.2484.
Psoriasis is one of the major problems facing dermatologists worldwide. Planar arrays of light-emitting diodes (LEDs) have recently attracted attention in the treatment of difficult dermatological entities, 830 nm in near infrared (near-IR) and 633 nm in visible red. This study was designed to assess the efficacy of combination 830-nm and 633-nm LED phototherapy in the treatment of recalcitrant psoriasis.
Nine informed and consenting patients with psoriasis were enrolled in this preliminary study, (3 men, 6 women, mean age 34.3, skin types I to IV). All had chronic psoriasis, which in most cases had proved resistant to conventional treatments. They were treated sequentially with LED arrays delivering continuous-wave 830 nm (near-IR) and 633 nm (red) in two 20-min sessions over 4 or 5 weeks, with 48 h between sessions (830 nm, 60 J/cm(2); 633 nm, 126 J/cm(2)).
All patients completed their LED regimens (4 requiring 1 regimen, 5 requiring a second). Follow-up periods were from 3 to 8 months, except in two patients who were lost to follow-up. Clearance rates at the end of the follow-up period ranged from 60% to 100%. Satisfaction was universally very high.
The antiinflammatory effects of LED energy at 830 nm and 633 nm have been well documented, as has their use in wound healing. LED phototherapy is easy to apply, pain free and side-effect free, and is well tolerated by patients of all skin types. The promising results of this preliminary study warrant a proper controlled double-blind study with a larger patient population.
银屑病是全球皮肤科医生面临的主要问题之一。发光二极管（LED）平面阵列最近在治疗难治性皮肤病方面引起了关注，近红外（near-IR）波段为830 nm，可见红光波段为633 nm。本研究旨在评估830 nm和633 nm LED联合光疗对顽固性银屑病的治疗效果。
9名知悉并同意参与研究的银屑病患者纳入本初步研究（3名男性，6名女性，平均年龄34.3岁，皮肤类型为I至IV型）。所有患者均患有慢性银屑病，大多数病例对传统治疗耐药。他们在4或5周内分两个20分钟疗程依次接受发射连续波830 nm（近红外）和633 nm（红色）的LED阵列治疗，疗程间隔48小时（830 nm，60 J/cm²；633 nm，126 J/cm²）。
所有患者均完成了LED治疗方案（4名患者需要1个疗程，5名患者需要第2个疗程）。随访期为3至8个月，但有两名患者失访。随访期末的清除率为60%至100%。患者普遍满意度很高。
830 nm和633 nm的LED能量的抗炎作用以及它们在伤口愈合中的应用已有充分记录。LED光疗易于实施，无痛且无副作用，所有皮肤类型的患者耐受性良好。这项初步研究的良好结果值得进行一项适当的、有更大患者群体的对照双盲研究。
