挠痒痒调控秀丽隐杆线虫生殖干细胞的壁龛。
Scratching the niche that controls Caenorhabditis elegans germline stem cells.
机构信息
Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA.
出版信息
Semin Cell Dev Biol. 2009 Dec;20(9):1107-13. doi: 10.1016/j.semcdb.2009.09.005. Epub 2009 Sep 16.
Abstract
The Caenorhabditis elegans gonad provides a well-defined model for a stem cell niche and its control of self-renewal and differentiation. The distal tip cell (DTC) forms a mesenchymal niche that controls germline stem cells (GSCs), both to generate the germline tissue during development and to maintain it during adulthood. The DTC uses GLP-1/Notch signaling to regulate GSCs; germ cells respond to Notch signaling with a network of RNA regulators to control the decision between self-renewal and entry into the meiotic cell cycle.
摘要
秀丽隐杆线虫的性腺为干细胞生态位及其对自我更新和分化的控制提供了一个明确的模型。远端生殖系起始细胞（DTC）形成了一个间质生态位，控制生殖干细胞（GSCs），既能在发育过程中产生生殖系组织，又能在成年期维持生殖系组织。DTC 利用 GLP-1/Notch 信号来调节 GSCs；生殖细胞通过一个 RNA 调控网络对 Notch 信号做出反应，以控制自我更新和进入减数分裂细胞周期之间的决策。
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