Schiehser Dawn M, Han S Duke, Lessig Stephanie, Song David D, Zizak Vanessa, Filoteo J Vincent
Department of Psychiatry, Univeristy of California of San Diego, San Diego, CA, USA.
Arch Clin Neuropsychol. 2009 Nov;24(7):699-709. doi: 10.1093/arclin/acp064. Epub 2009 Sep 18.
Recent studies have shown that self-perceived health status (HS) in Parkinson's disease (PD) is associated with motor, cognitive, or mood symptoms, with the greatest association typically occurring with mood. The purpose of this study was to determine if these associations are present in nondepressed and nondemented individuals with PD by using sensitive neuropsychological measures and statistically derived factors from mood and motor scales. The best predictors of poor HS in PD participants (N = 32) without dementia or depression were mood symptoms, specific to self-reported cognitive impairment and anxiety. Bivariate correlations between HS and number of correct categories on the Wisconsin Card Sorting Test and the gait-balance factor from the Unified Parkinson's Disease Rating Scale Part III were also significant or approached significance. These findings suggest that specific mood and cognitive symptoms continue to be important factors in HS in those individuals who lack clinical levels of depression or dementia.
最近的研究表明，帕金森病（PD）患者的自我感知健康状况（HS）与运动、认知或情绪症状相关，其中通常与情绪的关联最为密切。本研究的目的是通过使用敏感的神经心理学测量方法以及从情绪和运动量表中统计得出的因素，来确定这些关联是否存在于无抑郁和无痴呆的PD患者中。在没有痴呆或抑郁的PD参与者（N = 32）中，HS较差的最佳预测因素是情绪症状，具体表现为自我报告的认知障碍和焦虑。HS与威斯康星卡片分类测验上正确分类的数量以及统一帕金森病评定量表第三部分的步态平衡因子之间的双变量相关性也显著或接近显著。这些发现表明，对于那些没有临床抑郁或痴呆水平的个体，特定的情绪和认知症状仍然是HS的重要因素。
