Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Parkinsonism Relat Disord. 2011 May;17(4):249-54. doi: 10.1016/j.parkreldis.2011.01.005. Epub 2011 Feb 2.
Both anxiety and depression are associated with lower self-perceived health status (HS) in persons with Parkinson's disease (PD). Given the high co-morbidity with depression and other non-motor symptoms, it is unclear whether anxiety disorders, in general, versus specific anxiety subtypes have an independent effect on HS in PD. To examine this question, comprehensive assessments of motor and non-motor symptoms from 249 subjects with idiopathic PD followed in three community-based movement disorders neurology practices were analyzed. HS was measured using the 8-item PD Questionnaire (PDQ-8). Psychiatric diagnoses were established by consensus using a panel of six psychiatrists with expertise in geriatric psychiatry and movement disorders. Stepwise multiple regression analyses were used, with the PDQ-8 score as the dependent variable, to identify independent predictors of HS among motor, psychiatric, and other non-motor variables. Among the anxiety disorders, only anxiety associated with motor fluctuations was an independent predictor of HS after accounting for co-morbid depression and other clinical features. In addition, depressive disorders were also an independent predictor of lower HS. Prevention or treatment of state-dependent anxiety may improve HS in persons with PD.
焦虑和抑郁与帕金森病（PD）患者的自我感知健康状况（HS）较低有关。鉴于与抑郁和其他非运动症状的高共病率，尚不清楚一般焦虑症与特定焦虑症亚型是否对 PD 中的 HS 有独立影响。为了研究这个问题，对在三个社区为基础的运动障碍神经病学实践中接受治疗的 249 名特发性 PD 患者进行了全面的运动和非运动症状评估。HS 使用 8 项 PD 问卷（PDQ-8）进行测量。精神病学诊断是使用一组六位具有老年精神病学和运动障碍专业知识的精神科医生的小组通过共识建立的。使用逐步多元回归分析，以 PDQ-8 评分为因变量，在运动、精神和其他非运动变量中确定 HS 的独立预测因子。在焦虑症中，只有与运动波动相关的焦虑症是在考虑到共病抑郁和其他临床特征后，HS 的独立预测因子。此外，抑郁障碍也是 HS 降低的独立预测因子。状态相关焦虑的预防或治疗可能会改善 PD 患者的 HS。
