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Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics.环肽大环化合物和环缩肽的渗透性及其作为治疗药物的潜力。
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The Potential of the Cyclotide Scaffold for Drug Development.环肽支架在药物开发中的潜力。
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本文引用的文献

1
Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization.环状蛋白质结构域的化学合成：折叠辅助环化的证据。
Angew Chem Int Ed Engl. 1998 Feb 16;37(3):347-349. doi: 10.1002/(SICI)1521-3773(19980216)37:3<347::AID-ANIE347>3.0.CO;2-5.
2
In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1.基于环肽 SFTI-1 的 Ala 扫描文库的体内生物合成。
Amino Acids. 2010 May;38(5):1313-22. doi: 10.1007/s00726-009-0338-4. Epub 2009 Aug 14.
3
"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides.“拼接式”药物发现。基于细胞的骨架环化多肽基因编码文库的表达与筛选。
Adv Drug Deliv Rev. 2009 Sep 30;61(11):908-17. doi: 10.1016/j.addr.2009.07.003. Epub 2009 Jul 21.
4
Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins.天然及工程化胱氨酸结微型蛋白的生物多样性与治疗潜力。
Curr Opin Pharmacol. 2009 Oct;9(5):608-14. doi: 10.1016/j.coph.2009.05.004. Epub 2009 Jun 10.
5
The discovery and development of a natural combinatorial peptide template: the cyclotides.一种天然组合肽模板——环肽的发现与开发。
Adv Exp Med Biol. 2009;611:477-8. doi: 10.1007/978-0-387-73657-0_205.
6
Knottin cyclization: impact on structure and dynamics.结蛋白环化：对结构和动力学的影响。
BMC Struct Biol. 2008 Dec 12;8:54. doi: 10.1186/1472-6807-8-54.
7
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.天然和工程化MCoTI环肽的化学合成与仿生全合成。
Org Biomol Chem. 2008 Apr 21;6(8):1462-70. doi: 10.1039/b801667d. Epub 2008 Mar 6.
8
Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.对原型环肽进行丙氨酸扫描诱变揭示了一组对生物活性至关重要的残基。
J Biol Chem. 2008 Apr 11;283(15):9805-13. doi: 10.1074/jbc.M709303200. Epub 2008 Feb 7.
9
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.环状胱氨酸结微小蛋白MCoTI-II通过巨胞饮作用内化进入细胞。
Int J Biochem Cell Biol. 2007;39(12):2252-64. doi: 10.1016/j.biocel.2007.06.016. Epub 2007 Jul 7.
10
Biosynthesis of a fully functional cyclotide inside living bacterial cells.在活细菌细胞内生物合成具有完整功能的环肽。
Chembiochem. 2007 Aug 13;8(12):1363-6. doi: 10.1002/cbic.200700183.

Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.

作者信息

Austin Jeffrey, Wang Wan, Puttamadappa Swamy, Shekhtman Alexander, Camarero Julio A

机构信息

Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

出版信息

Chembiochem. 2009 Nov 2;10(16):2663-70. doi: 10.1002/cbic.200900534.

DOI:10.1002/cbic.200900534
PMID:19780078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2940853/
Abstract
摘要