Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.
作者信息
Austin Jeffrey, Wang Wan, Puttamadappa Swamy, Shekhtman Alexander, Camarero Julio A
机构信息
Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
出版信息
Chembiochem. 2009 Nov 2;10(16):2663-70. doi: 10.1002/cbic.200900534.
Abstract
摘要
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本文引用的文献
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Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization.环状蛋白质结构域的化学合成：折叠辅助环化的证据。
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In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1.基于环肽 SFTI-1 的 Ala 扫描文库的体内生物合成。
Amino Acids. 2010 May;38(5):1313-22. doi: 10.1007/s00726-009-0338-4. Epub 2009 Aug 14.
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"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides.“拼接式”药物发现。基于细胞的骨架环化多肽基因编码文库的表达与筛选。
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