Matricardi Pietro, Cencetti Claudia, Ria Roberto, Alhaique Franco, Coviello Tommasina
Department of Drug Chemistry and Technologies, Faculty of Pharmacy, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Molecules. 2009 Sep 3;14(9):3376-91. doi: 10.3390/molecules14093376.
Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was also investigated and the trend of the release profiles has been related to the structures proposed for the physical and the chemical hydrogel.
通过脱酰基结冷胶的物理和化学交联获得的新型水凝胶已在吸水性、流变学性质和压缩性方面进行了表征，并且根据所得网络的类型，对测试材料的行为进行了深入讨论。还研究了不同空间位阻的负载模型分子从各种凝胶中的释放情况，并且释放曲线的趋势已与物理和化学水凝胶所提出的结构相关联。
