Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Acta Paediatr. 2010 Jan;99(1):37-41. doi: 10.1111/j.1651-2227.2009.01516.x.
We investigated the relationship between plasma insulin-like growth factor I (IGF-I), leptin, active ghrelin levels, and postnatal growth in very low birth weight (VLBW) infants.
Plasma IGF-I, leptin, and active ghrelin levels were measured at birth and at 2, 4, 6 and 8 weeks after birth in 61 VLBW infants, including 31 appropriate-for-gestational-age (AGA) and 30 small-for-gestational-age (SGA) infants.
Insulin-like growth factor I levels were the lowest at birth, but increased gradually over the first 8 weeks of life. IGF-I was positively correlated with body weight, body length and body mass index at all time points. Leptin levels did not change over the study period. Ghrelin levels were significantly lower at birth; however, there were no significant differences between the levels after 2 weeks of age. Leptin and ghrelin levels were not correlated with anthropometrical measures. IGF-I levels at birth were significantly lower in SGA than in AGA infants, but the leptin and ghrelin levels were not significantly different between the two groups.
Insulin-like growth factor I is related to length and weight gain in the prenatal and the early postnatal periods in VLBW infants, but this does not appear to be the case for leptin and ghrelin.
我们研究了极低出生体重（VLBW）婴儿血浆胰岛素样生长因子 I（IGF-I）、瘦素和活性胃饥饿素水平与出生后生长的关系。
测量了 61 名 VLBW 婴儿（包括 31 名适于胎龄（AGA）和 30 名小于胎龄（SGA）婴儿）在出生时以及出生后 2、4、6 和 8 周时的血浆 IGF-I、瘦素和活性胃饥饿素水平。
IGF-I 水平在出生时最低，但在生命的前 8 周内逐渐升高。IGF-I 与所有时间点的体重、身长和体重指数呈正相关。研究期间瘦素水平没有变化。出生时胃饥饿素水平明显较低，但 2 周龄后水平无显著差异。瘦素和胃饥饿素水平与人体测量指标无关。SGA 婴儿出生时 IGF-I 水平明显低于 AGA 婴儿，但两组间瘦素和胃饥饿素水平无显著差异。
IGF-I 与 VLBW 婴儿产前和出生后早期的身高和体重增长有关，但瘦素和胃饥饿素似乎并非如此。
