使用正电子发射断层扫描先验进行小动物成像的三维荧光光学层析成像。
Three-dimensional fluorescence optical tomography in small-animal imaging using simultaneous positron-emission-tomography priors.
机构信息
Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA.
出版信息
Opt Lett. 2009 Oct 1;34(19):2933-5. doi: 10.1364/OL.34.002933.
Abstract
We propose three-dimensional fluorescence optical tomography imaging for small animals guided by simultaneous priors from positron emission tomography (PET). Using a sparsity regularization, the target prior from PET images was incorporated into the reconstruction algorithm for optical imaging. The method and algorithms are validated with numerical simulations and a phantom experiment performed on a combined optical-PET scanner based on a conical mirror geometry.
摘要
我们提出了一种基于正电子发射断层扫描 (PET) 同时先验信息引导的小动物三维荧光光学断层成像方法。利用稀疏正则化，将 PET 图像的目标先验信息纳入光学成像的重建算法中。该方法和算法通过数值模拟和基于锥形镜几何结构的光学-PET 扫描仪上的 phantom 实验进行了验证。
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