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Molecular analysis of the pathogenesis of beta-cell destruction in insulin-dependent diabetes mellitus.

作者信息

Lernmark A, Bärmeier H, Dube S, Hagopian W, Karlsen A E, Markholst H, Wilson C, Wassmuth R

机构信息

R. H. Williams Laboratory, Department of Medicine, University of Washington School of Medicine, Seattle 98195.

出版信息

West J Med. 1990 Nov;153(5):499-502.

PMID:1979704
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1002598/
Abstract
摘要

相似文献

1
Molecular analysis of the pathogenesis of beta-cell destruction in insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病中β细胞破坏发病机制的分子分析
West J Med. 1990 Nov;153(5):499-502.
2
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.HLA-DQβ基因与胰岛素依赖型糖尿病的易感性和抗性有关。
Nature. 1987;329(6140):599-604. doi: 10.1038/329599a0.
3
[Mechanism and genetic control of the autoimmune response directed against beta-pancreatic cells in insulin-dependent diabetes].[胰岛素依赖型糖尿病中针对β胰腺细胞的自身免疫反应的机制与遗传控制]
Journ Annu Diabetol Hotel Dieu. 1985:171-82.
4
Immunoreactivity to a 64,000 Mr human islet cell antigen in sera from insulin-dependent diabetes mellitus patients and individuals with abnormal glucose tolerance.胰岛素依赖型糖尿病患者及糖耐量异常个体血清中对64,000 Mr人胰岛细胞抗原的免疫反应性。
Mol Biol Med. 1986 Apr;3(2):137-42.
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HLA DQ alpha/beta molecule associated with the susceptibility to insulin-dependent diabetes mellitus. A model for HLA/autoimmune disease association.与胰岛素依赖型糖尿病易感性相关的HLA DQα/β分子。HLA/自身免疫性疾病关联模型。
Nouv Rev Fr Hematol (1978). 1990;32(6):445-7.
6
Autoantibodies in type 1 diabetes.1型糖尿病中的自身抗体。
Autoimmunity. 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169.
7
[The pathogenesis of type 1 diabetes mellitus].[1型糖尿病的发病机制]
Ther Umsch. 1990 Jan;47(1):15-21.
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Restriction fragment polymorphisms of the HLA-DR, HLA-DQ, and insulin gene regions in IDDM: the GAW5 data.胰岛素依赖型糖尿病中HLA - DR、HLA - DQ和胰岛素基因区域的限制性片段多态性：GAW5数据
Genet Epidemiol. 1989;6(1):21-6. doi: 10.1002/gepi.1370060106.
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Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.赋予胰岛素依赖型糖尿病易感性或保护性的HLA - DQ等位基因的分子特性：胰岛β细胞命运的关键
Am J Med Genet. 2002 May 30;115(1):37-47. doi: 10.1002/ajmg.10342.
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The pathogenesis of insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病的发病机制。
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引用本文的文献

1
Gene therapy in diabetes.糖尿病中的基因治疗。
Self Nonself. 2010 Jul;1(3):165-175. doi: 10.4161/self.1.3.12643. Epub 2010 Jun 9.

本文引用的文献

1
Abnormalities of immunoregulatory T cell subsets in patients with insulin-dependent diabetes mellitus.
J Immunol. 1982 Oct;129(4):1426-9.
2
Pathologic anatomy of the pancreas in juvenile diabetes mellitus.青少年糖尿病患者胰腺的病理解剖
Diabetes. 1965 Oct;14(10):619-33. doi: 10.2337/diab.14.10.619.
3
Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans.亲和纯化的人白细胞介素I对分离的胰岛具有细胞毒性。
Diabetologia. 1986 Jan;29(1):63-7. doi: 10.1007/BF02427283.
4
A molecular basis for MHC class II--associated autoimmunity.MHC II类相关自身免疫的分子基础。
Science. 1988 May 20;240(4855):1003-9. doi: 10.1126/science.3368786.
5
Structure of the human class I histocompatibility antigen, HLA-A2.人类I类组织相容性抗原HLA - A2的结构
Nature. 1987;329(6139):506-12. doi: 10.1038/329506a0.
6
The BB rat.BB大鼠。
Diabetes Metab Rev. 1987 Jul;3(3):725-50. doi: 10.1002/dmr.5610030307.
7
The second International Workshop on the Standardisation of Insulin Autoantibody (IAA) measurement. Held in New York, 27-30 October 1987.
Diabetologia. 1988 Jul;31(7):449-50. doi: 10.1007/BF00271590.
8
Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies.
J Immunol Methods. 1988 Jan 21;106(1):83-8. doi: 10.1016/0022-1759(88)90274-8.
9
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration.白细胞介素1对大鼠胰腺β细胞的双峰效应——先刺激后抑制——取决于剂量、暴露持续时间和周围葡萄糖浓度。
Acta Endocrinol (Copenh). 1988 Oct;119(2):307-11. doi: 10.1530/acta.0.1190307.
10
Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.HLA - DQ亚区域的特定基因组标记可区分DR4阳性的胰岛素依赖型糖尿病和DR4阳性的血清阳性青少年类风湿性关节炎。
J Exp Med. 1986 Jul 1;164(1):345-50. doi: 10.1084/jem.164.1.345.