Orthodontics, Faculty of Dentistry, University of Hong Kong China, Hong Kong SAR, China.
Eur J Orthod. 2010 Aug;32(4):435-40. doi: 10.1093/ejo/cjp108. Epub 2009 Oct 11.
The aim of this study was to evaluate the effects of orthodontic treatment on systemic levels of the inflammatory markers, C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). The study group comprised 11 girls and 6 boys (mean age 13.1 years) treated with fixed appliances and distalizing headgear. Venous blood samples were taken from the cubital vein of each subject before treatment (T0) and then at three further time points during treatment (T1-T3), 2 months apart. The sera from these blood samples were analysed using enzyme-linked immunosorbent assay (ELISA) assay technology for CRP, TNF-alpha, and IL-6 concentration levels. Data were compared between baseline and subsequent sequential time points using a Mann-Whitney test for non-normally distributed variables. The results showed that there was no significant elevation of any of the three inflammatory markers at any of the time points. This research provides evidence that conventional orthodontic treatment is not associated with a systemic immune response in the factors investigated.
本研究旨在评估正畸治疗对系统性炎症标志物 C 反应蛋白 (CRP)、肿瘤坏死因子-α (TNF-α) 和白细胞介素-6 (IL-6) 水平的影响。研究组包括 11 名女孩和 6 名男孩（平均年龄 13.1 岁），他们接受了固定矫治器和远移头帽治疗。在治疗前（T0）和治疗期间的另外三个时间点（T1-T3），每隔 2 个月从每个受试者的肘静脉采集静脉血样本。使用酶联免疫吸附测定 (ELISA) 技术分析这些血样的血清 CRP、TNF-α 和 IL-6 浓度水平。使用非正态分布变量的曼-惠特尼检验比较基线与后续连续时间点之间的数据。结果表明，在任何时间点，这三种炎症标志物均无显著升高。这项研究提供了证据，表明常规正畸治疗与所研究因素的全身免疫反应无关。
