Ali Mahmood Trefa Mohammed, Chawshli Omar Fawzi
Department of Pedodontics, Orthodontics and Preventive Dentistry, College of Dentistry, University of Sulaimani, Sulaymaniyah, Kurdistan Region, Iraq.
Department of Pedodontics, Orthodontics and Preventive Dentistry, College of Dentistry, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Int J Inflam. 2019 Oct 1;2019:6715871. doi: 10.1155/2019/6715871. eCollection 2019.
The present study aims to reveal the systemic effects of submucosal injection of plasma-rich platelets (PRP) on blood inflammatory markers which was used in an attempt to reduce the retraction time of the upper canine following extraction of upper maxillary premolars for patients with bimaxillary protrusion.
No change on comparing the values of blood inflammatory markers before and after submucosal injection of PRP.
Eighteen female patients with bimaxillary protusion were selected from patients seeking orthodontic treatment from the College of Dentistry/University of Sulaimai, whose maxillary and mandibular first premolars were decided to be extracted after proper diagnosis. Thirty-three blood markers (twenty hematological and thirteen biochemical markers) were estimated before orthodontic bracketing, 24 hours and 7 days following submucosal injection of PRP (5 cc) to reveal the systematic effect of PRP on blood inflammatory markers that were used in an attempt to reduce the retraction time of the upper canine following extraction of upper maxillary premolars for patients with bimaxillary protrusion.
The results indicate nonsignificant differences in the values of all blood markers except for gamma GT (GGT), PDWa, serum albumin, serum total protein, and total calcium. Gamma level significantly increased for both test intervals. On the other hand, there was a significant drop in the value of PDWa while for alkaline phosphatase, there was a drop within the first 24 hr of PRP injection while after 7 days the value was significantly increased. On the other hand, there was a drop in the level of serum albumin, while there was an increase in the serum total protein and total calcium.
Submucosal injection of PRP could lead to systematic alteration of blood parameters including ALK phosphatase, gamma GT, serum albumin, and serum total protein, which may be related to liver function in addition to increase in the level of PDWa and serum calcium. We present evidence that PRP contains and may trigger systemic effect. Thus, further investigation is recommended to follow up the patient for a longer period of time and on a larger sample. This trial is registered with U1111-1221-8829 by Sri Lanka Clinical Trial Registry, SLCTR/2018/040, and No. 64 on 6 August 2018 at the local clinical studies database, College of Dentistry.
本研究旨在揭示对上颌前磨牙拔除后行黏膜下注射富血小板血浆（PRP）对血液炎症标志物的全身影响，该方法用于尝试缩短双颌前突患者上颌尖牙的回缩时间。
黏膜下注射PRP前后血液炎症标志物的值无变化。
从苏莱曼尼亚大学牙科学院寻求正畸治疗的患者中选取18名双颌前突女性患者，在正确诊断后决定拔除其上颌和下颌第一前磨牙。在正畸托槽粘接前、黏膜下注射PRP（5 cc）后24小时和7天，对33项血液标志物（20项血液学标志物和13项生化标志物）进行评估，以揭示PRP对血液炎症标志物的全身影响，该方法用于尝试缩短双颌前突患者上颌前磨牙拔除后上颌尖牙的回缩时间。
结果表明，除γ-谷氨酰转移酶（GGT）、血小板分布宽度（PDWa）、血清白蛋白、血清总蛋白和总钙外，所有血液标志物的值均无显著差异。两个测试时间段的γ水平均显著升高。另一方面，PDWa值显著下降，而碱性磷酸酶在PRP注射后的前24小时内下降，7天后值显著升高。另一方面，血清白蛋白水平下降，而血清总蛋白和总钙水平升高。
黏膜下注射PRP可导致包括碱性磷酸酶、γ-GT、血清白蛋白和血清总蛋白在内的血液参数发生系统性改变，这可能与肝功能有关，此外还会导致PDWa和血清钙水平升高。我们提供的证据表明PRP含有并可能引发全身效应。因此，建议进一步研究，对患者进行更长时间、更大样本量的随访。本试验已在斯里兰卡临床试验注册中心注册，注册号为U1111-1221-8829，SLCTR/2018/040，于2018年8月6日在牙科学院当地临床研究数据库中登记为第64号。
