Laboratory of Information and Research on Bone Diseases (LIRPOS), Department of Rheumatology, El Ayachi hospital, University Hospital of Rabat-Sale, Morocco.
BMC Public Health. 2009 Oct 14;9:388. doi: 10.1186/1471-2458-9-388.
Some studies have implicated several possible metabolic linkages between osteoporosis and vascular calcification, including estrogen deficiency, vitamin D excess, vitamin K deficiency and lipid oxidation products. Nevertheless, it remains unclear whether osteoporosis and atherosclerosis are related to each other or are independent processes, both related to aging. The aim of this cross-sectional study was to evaluate the correlation between arterial thickening and bone status in a sample of apparently healthy Moroccan women.
Seventy-two postmenopausal women were studied. All patients were without secondary causes that might affect bone density. Bone status was assessed by bone mineral density (BMD) in lumbar spine and all femoral sites. Arterial wall thickening was assessed by intima-media thickness (IMT) in carotid artery (CA) and femoral artery (FA). Prevalent plaques were categorized into four groups ranging from low echogenicity to high echogenicity.
The mean age was 59.2 +/- 8.3 years. 84.7% had at least one plaque. By Spearman Rank correlation, CA IMT was negatively correlated to Femoral total BMD (r = -0.33), Femoral neck BMD (r = -0.23), Ward triangle BMD (r = -0.30) and Trochanter BMD (r = -0.28) while there was no association with lumbar BMD. In multiple regression analysis, CA IMT emerged as an independent factor significantly associated with all femoral sites BMD after adjusting of confounding factors. FA IMT failed to be significantly associated with both Femoral and Lumbar BMD. No significant differences between echogenic, predominantly echogenic, predominantly echolucent and echolucent plaques groups were found concerning lumbar BMD and all femoral sites BMD CONCLUSION: Our results demonstrate a negative correlation between bone mineral density (BMD) qnd carotid intima-media thickness (IMT) in postmenopausal women, independently of confounding factors. We suggest that bone status should be evaluated in patients with vascular disease to assess whether preventive or therapeutic intervention is necessarry.
一些研究表明骨质疏松症和血管钙化之间存在几种可能的代谢联系，包括雌激素缺乏、维生素 D 过量、维生素 K 缺乏和脂质氧化产物。然而，目前尚不清楚骨质疏松症和动脉粥样硬化是否相互关联，还是与衰老相关的两个独立过程。本横断面研究旨在评估摩洛哥绝经后女性样本中动脉壁增厚与骨状态之间的相关性。
共纳入 72 例绝经后女性。所有患者均无影响骨密度的继发性疾病。通过腰椎和所有股骨部位的骨矿物质密度（BMD）评估骨状态。通过颈动脉（CA）和股动脉（FA）的内膜中层厚度（IMT）评估动脉壁增厚。将动脉粥样硬化斑块分为四个回声强度组。
平均年龄为 59.2±8.3 岁，84.7%的患者至少有一个斑块。Spearman 秩相关分析显示，CA IMT 与股骨总 BMD（r=-0.33）、股骨颈 BMD（r=-0.23）、Ward 三角 BMD（r=-0.30）和转子 BMD（r=-0.28）呈负相关，而与腰椎 BMD 无相关性。在多元回归分析中，校正混杂因素后，CA IMT 是与所有股骨部位 BMD 显著相关的独立因素。FA IMT 与股骨和腰椎 BMD 均无显著相关性。回声、回声为主、回声为主伴低回声和低回声斑块组之间的腰椎 BMD 和所有股骨部位 BMD 无显著差异。
我们的研究结果表明，绝经后妇女的骨矿物质密度（BMD）与颈动脉内膜中层厚度（IMT）之间存在负相关，且不受混杂因素的影响。我们建议对患有血管疾病的患者进行骨状态评估，以确定是否需要预防性或治疗性干预。
