Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
J Virol. 2010 Jan;84(1):21-6. doi: 10.1128/JVI.01732-09.
Novel swine-origin influenza viruses of the H1N1 subtype were first detected in humans in April 2009. As of 12 August 2009, 180,000 cases had been reported globally. Despite the fact that they are of the same antigenic subtype as seasonal influenza viruses circulating in humans since 1977, these viruses continue to spread and have caused the first influenza pandemic since 1968. Here we show that a pandemic H1N1 strain replicates in and transmits among guinea pigs with similar efficiency to that of a seasonal H3N2 influenza virus. This transmission was, however, partially disrupted when guinea pigs had preexisting immunity to recent human isolates of either the H1N1 or H3N2 subtype and was fully blocked through daily intranasal administration of interferon to either inoculated or exposed animals. Our results suggest that partial immunity resulting from prior exposure to conventional human strains may blunt the impact of pandemic H1N1 viruses in the human population. In addition, the use of interferon as an antiviral prophylaxis may be an effective way to limit spread in at-risk populations.
新型猪源 H1N1 亚型流感病毒于 2009 年 4 月首次在人类中被发现。截至 2009 年 8 月 12 日，全球已报告 18 万例病例。尽管这些病毒与自 1977 年以来在人类中流行的季节性流感病毒具有相同的抗原亚型，但它们仍在继续传播，并引发了自 1968 年以来的首次流感大流行。在这里，我们表明一种大流行的 H1N1 株在豚鼠体内复制和传播的效率与季节性 H3N2 流感病毒相似。然而，当豚鼠对最近的 H1N1 或 H3N2 亚型的人类分离株存在预先存在的免疫时，这种传播被部分破坏，并且通过每天向接种或暴露的动物鼻内给予干扰素完全阻断。我们的结果表明，由于先前接触常规人类株而产生的部分免疫可能会削弱大流行 H1N1 病毒在人群中的影响。此外，使用干扰素作为抗病毒预防可能是限制高危人群传播的有效方法。
