Department of Radiology, Barnes-Jewish Hospital, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Cardiol Rev. 2009 Nov-Dec;17(6):283-6. doi: 10.1097/CRD.0b013e3181b3fe0d.
This article focuses on a newly discovered bioactive peptide, termed apelin, as it relates to the cardiovascular system. Apelin, through its G-protein coupled receptor, seems to primarily exert effects in blood pressure control, and may play a role in heart failure and in myocardial reperfusion injury. In addition, at least some of apelin's effects appear to stem from an interaction with the renin-angiotensin system. Apelin may provide a target for drug treatment of cardiovascular disease.
本文主要探讨一种新发现的生物活性肽——apelin，及其与心血管系统的关系。apelin 通过其 G 蛋白偶联受体，似乎主要对血压控制产生影响，并可能在心力衰竭和心肌再灌注损伤中发挥作用。此外，apelin 的至少部分作用似乎源于与肾素-血管紧张素系统的相互作用。apelin 可能为心血管疾病的药物治疗提供了一个靶点。
