Maternal & Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester, UK.
BJOG. 2010 Jan;117(2):200-11. doi: 10.1111/j.1471-0528.2009.02371.x.
Teenagers are susceptible to delivering small-for-gestational-age (SGA) infants. Previous studies suggest that maternal growth may contribute, as a result of preferential nutrient partitioning to the mother. We investigated the impact of maternal growth on birthweight in pregnant teenagers in the UK, and examined endocrine mediators of nutrient partitioning.
A prospective observational multicentre study, About Teenage Eating, conducted between 2004 and 2007.
Four hospitals in socially-deprived areas of Manchester and London.
A total of 500 pregnant adolescents (14-18 years of age) with a singleton pregnancy were recruited at 10-21 weeks of gestation, with follow-up studies on 368 subjects. A cohort of 80 pregnant adults (25-40 years of age) provided a control group for determining growth.
Skeletal growth, weight gain and skinfold thickness were measured from first to third trimester, together with maternal levels of micronutrients and metabolic hormones: insulin-like growth factor (IGF) system and leptin. Dietary analyses were performed.
SGA birth.
Maternal growth was not associated with SGA birth: growing mothers delivered more large-for-gestational-age infants (OR 2.51; P < 0.05). Growers had greater weight gain (P < 0.001), fat accrual (P < 0.001) and red cell folate concentrations (P < 0.01) than non-growers. Maternal IGF-I (P < 0.01) and leptin (P < 0.001) were positively associated with maternal and fetal growth, whereas IGF-I (P < 0.001) was negatively associated. Teenagers that were underweight at booking or with low weight gain were at greater risk of SGA birth.
Maternal growth was not detrimental to fetal growth in this UK population of teenagers. Greater weight gain and higher concentrations of IGF-I in growing teenagers may provide anabolic drive for maternal and fetal growth.
青少年容易生育小于胎龄儿（SGA）。先前的研究表明，由于母体营养的优先分配，母体生长可能会产生影响。我们研究了英国青少年母亲的生长对胎儿出生体重的影响，并探讨了营养分配的内分泌介质。
一项在 2004 年至 2007 年间进行的、关于青少年饮食的前瞻性观察性多中心研究。
曼彻斯特和伦敦社会贫困地区的四家医院。
共招募了 500 名怀孕青少年（14-18 岁），妊娠 10-21 周时进行了随访研究，有 368 名受试者。一个 80 名怀孕成年人（25-40 岁）的队列为确定生长提供了对照组。
从第一孕期到第三孕期测量骨骼生长、体重增加和皮褶厚度，同时测量母体的微量营养素和代谢激素：胰岛素样生长因子（IGF）系统和瘦素。进行了饮食分析。
SGA 出生。
母体生长与 SGA 出生无关：生长的母亲生育了更多的大于胎龄儿（OR 2.51；P <0.05）。生长者的体重增加（P <0.001）、脂肪堆积（P <0.001）和红细胞叶酸浓度（P <0.01）均大于非生长者。母体 IGF-I（P <0.01）和瘦素（P <0.001）与母体和胎儿生长呈正相关，而 IGF-I（P <0.001）与母体生长呈负相关。在预约时体重不足或体重增加较低的青少年更有可能发生 SGA 出生。
在英国青少年人群中，母体生长对胎儿生长没有不利影响。生长中的青少年体重增加较多，IGF-I 浓度较高，可能为母体和胎儿生长提供合成代谢动力。
