Patel Shyamal, Lorincz Konrad, Hughes Richard, Huggins Nancy, Growdon John, Standaert David, Akay Metin, Dy Jennifer, Welsh Matt, Bonato Paolo
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA 02114, USA.
IEEE Trans Inf Technol Biomed. 2009 Nov;13(6):864-73. doi: 10.1109/TITB.2009.2033471. Epub 2009 Oct 20.
This paper presents the results of a pilot study to assess the feasibility of using accelerometer data to estimate the severity of symptoms and motor complications in patients with Parkinson's disease. A support vector machine (SVM) classifier was implemented to estimate the severity of tremor, bradykinesia and dyskinesia from accelerometer data features. SVM-based estimates were compared with clinical scores derived via visual inspection of video recordings taken while patients performed a series of standardized motor tasks. The analysis of the video recordings was performed by clinicians trained in the use of scales for the assessment of the severity of Parkinsonian symptoms and motor complications. Results derived from the accelerometer time series were analyzed to assess the effect on the estimation of clinical scores of the duration of the window utilized to derive segments (to eventually compute data features) from the accelerometer data, the use of different SVM kernels and misclassification cost values, and the use of data features derived from different motor tasks. Results were also analyzed to assess which combinations of data features carried enough information to reliably assess the severity of symptoms and motor complications. Combinations of data features were compared taking into consideration the computational cost associated with estimating each data feature on the nodes of a body sensor network and the effect of using such data features on the reliability of SVM-based estimates of the severity of Parkinsonian symptoms and motor complications.
本文介绍了一项初步研究的结果,该研究旨在评估利用加速度计数据估计帕金森病患者症状严重程度和运动并发症的可行性。实施了支持向量机(SVM)分类器,以根据加速度计数据特征估计震颤、运动迟缓及异动症的严重程度。基于支持向量机的估计值与通过对患者执行一系列标准化运动任务时拍摄的视频记录进行目视检查得出的临床评分进行了比较。视频记录的分析由接受过帕金森病症状和运动并发症严重程度评估量表使用培训的临床医生进行。对加速度计时间序列得出的结果进行了分析,以评估用于从加速度计数据中提取片段(最终计算数据特征)的窗口持续时间、不同支持向量机核函数和误分类成本值的使用,以及源自不同运动任务的数据特征的使用对临床评分估计的影响。还对结果进行了分析,以评估哪些数据特征组合携带了足够的信息来可靠地评估症状严重程度和运动并发症。在考虑与在身体传感器网络节点上估计每个数据特征相关的计算成本以及使用此类数据特征对基于支持向量机的帕金森病症状和运动并发症严重程度估计的可靠性的影响的情况下,对数据特征组合进行了比较。