Department of Cardiology, Gaziantep University, School of Medicine, Gaziantep, Turkey.
Tohoku J Exp Med. 2009 Nov;219(3):201-6. doi: 10.1620/tjem.219.201.
Being the most common cause of death from poisoning worldwide, cardiovascular manifestations of acute carbon monoxide (CO) poisoning have been subject of various studies but current evidence about effects of chronic CO exposure on atherosclerosis is limited which is very common. We aimed to investigate association of chronic CO exposure with atherosclerosis by measuring carotid intima-media thickness (CIMT) and high-sensitivity C-reactive protein (hs-CRP). Forty healthy male non-smoker indoor barbecue workers (mean age; 33.0 +/- 9.0 years) working in different restaurants for at least three years and 48 age-matched healthy men (mean age; 34.3 +/- 6.6 years) enrolled in the study. Clinical characteristics of indoor barbecue workers and control group were comparable in terms of body mass index, blood pressure, and lipid profile. However, carboxyhemoglobin (COHb) (6.4 +/- 1.5% vs. 2.0 +/- 1.1%), hs-CRP (2.7 +/- 2.0 mg/L vs. 1.1 +/- 0.8 mg/L) and CIMT (1.1 +/- 0.3 mm vs. 0.9 +/- 0.1 mm) were higher in indoor barbecue workers (p < 0.001 for each). In Pearson correlation analysis, CIMT was correlated with COHb concentration (r = 0.635, p < 0.001) and hs-CRP level (r = 0.466, p < 0.001). Among indoor barbecue workers, the years worked (years exposed to CO) are correlated with COHb, hs-CRP and CIMT. In multivariate analysis, COHb concentration is the only independent predictor of CIMT (beta = 0.571, p < 0.001). The increased CIMT and hs-CRP in indoor barbecue workers suggest that chronic CO exposure may increase the risk of atherosclerotic cardiovascular events.
作为全球范围内导致中毒死亡的最常见原因，急性一氧化碳（CO）中毒的心血管表现已经成为各种研究的主题，但目前关于慢性 CO 暴露对动脉粥样硬化影响的证据有限，而动脉粥样硬化是非常普遍的。我们旨在通过测量颈动脉内膜中层厚度（CIMT）和高敏 C 反应蛋白（hs-CRP）来研究慢性 CO 暴露与动脉粥样硬化之间的关系。我们招募了 40 名在不同餐厅工作至少三年的健康男性非吸烟室内烧烤工人（平均年龄 33.0 +/- 9.0 岁）和 48 名年龄匹配的健康男性（平均年龄 34.3 +/- 6.6 岁）作为对照组。室内烧烤工人和对照组的临床特征在体重指数、血压和血脂谱方面相当。然而，室内烧烤工人的血中碳氧血红蛋白（COHb）（6.4 +/- 1.5%比 2.0 +/- 1.1%）、高敏 C 反应蛋白（hs-CRP）（2.7 +/- 2.0 mg/L 比 1.1 +/- 0.8 mg/L）和 CIMT（1.1 +/- 0.3 mm 比 0.9 +/- 0.1 mm）更高（p < 0.001）。在 Pearson 相关分析中，CIMT 与 COHb 浓度（r = 0.635，p < 0.001）和 hs-CRP 水平（r = 0.466，p < 0.001）相关。在室内烧烤工人中，工作年限（暴露于 CO 的年限）与 COHb、hs-CRP 和 CIMT 相关。在多变量分析中，COHb 浓度是 CIMT 的唯一独立预测因子（β = 0.571，p < 0.001）。室内烧烤工人中 CIMT 和 hs-CRP 的增加表明，慢性 CO 暴露可能增加动脉粥样硬化心血管事件的风险。
