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Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporine A-treated, immunosuppressed rats.

作者信息

Stitz L, Schilken D, Frese K

机构信息

Institut für Virologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.

出版信息

J Virol. 1991 Jan;65(1):457-60. doi: 10.1128/JVI.65.1.457-460.1991.

Abstract

In adult rats infected with Borna disease virus, the virus was found exclusively in the brain, whereas in cyclosporine A-treated rats, infectious virus was also detected in peripheral nerve fibers and, unexpectedly, in adjacent organ-specific cells. In contrast to untreated virus-infected rats, no major histocompatibility complex class II expression was found in the brain of cyclosporine A-treated animals.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c080/240537/30b6d0ffc73b/jvirol00044-0479-a.jpg

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本文引用的文献

1
Borna disease in rhesus monkeys as a models for uveo-cerebral symptoms.
J Med Virol. 1981;6(4):333-40. doi: 10.1002/jmv.1890060408.
2
6
Adaptation of Borna disease virus to the mouse.博尔纳病病毒对小鼠的适应性
J Gen Virol. 1984 Oct;65 ( Pt 10):1845-9. doi: 10.1099/0022-1317-65-10-1845.
9
Borna disease in a sheep.绵羊的博尔纳病
Vet Rec. 1985 Nov 9;117(19):499-500. doi: 10.1136/vr.117.19.499.
10
The effects of cyclosporin A on the immune system.环孢素A对免疫系统的影响。
Annu Rev Immunol. 1985;3:397-423. doi: 10.1146/annurev.iy.03.040185.002145.

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