Institute of Information and Mathematical Sciences, Massey University, Albany, Auckland, New Zealand.
Respir Physiol Neurobiol. 2010 Jan 31;170(1):103-12. doi: 10.1016/j.resp.2009.10.008. Epub 2009 Oct 21.
We use a recently developed mathematical model that integrates a reduced representation of the brainstem respiratory neural controller together with peripheral gas exchange and transport to study numerically the dynamic response of the respiratory system to several physiological stimuli. We compare between the system responses with two major sources of delay: circulatory transport vs. neural feedback dynamics, and we show that the dynamics of the neural feedback processes dictates the dynamic response to hypoxia and hypercapnia. The source of the circulatory delay (blood velocity vs. distance from the lungs to chemoreceptors) was found to be important. Our model predicts that periodic breathing is associated with the ventilatory "afterdischarge" (slow recovery of ventilation) after a brief perturbation of CO(2). We also predict that there could be two possible mechanisms for the appearance of periodic breathing and that circulatory delay is not a necessary condition for this to occur in certain cases.
我们使用一种新开发的数学模型，该模型整合了脑干呼吸神经控制器的简化表示以及外周气体交换和传输，以数值方式研究呼吸系统对几种生理刺激的动态响应。我们比较了两个主要延迟源（循环传输与神经反馈动力学）的系统响应，并表明神经反馈过程的动力学决定了对低氧和高碳酸血症的动态响应。发现循环延迟的来源（血流速度与从肺部到化学感受器的距离）很重要。我们的模型预测，周期性呼吸与 CO2短暂扰动后的通气“后放电”（通气缓慢恢复）有关。我们还预测，周期性呼吸的出现可能有两种可能的机制，并且在某些情况下，循环延迟不是发生这种情况的必要条件。
