黄斑类胡萝卜素色素光密度测量及分布在年龄相关性黄斑变性和其他视网膜疾病中的价值。
The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders.
作者信息
Bernstein Paul S, Delori François C, Richer Stuart, van Kuijk Frederik J M, Wenzel Adam J
机构信息
Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
Vision Res. 2010 Mar 31;50(7):716-28. doi: 10.1016/j.visres.2009.10.014. Epub 2009 Oct 23.
Abstract
There is increasing recognition that the optical and antioxidant properties of the xanthophyll carotenoids lutein and zeaxanthin play an important role in maintaining the health and function of the human macula. In this review article, we assess the value of non-invasive quantification of macular pigment levels and distributions to identify individuals potentially at risk for visual disability or catastrophic vision loss from age-related macular degeneration, and we consider the strengths and weaknesses of the diverse measurement methods currently available.
摘要
叶黄素和玉米黄质这两种叶黄素类胡萝卜素的光学和抗氧化特性在维持人类黄斑的健康和功能方面发挥着重要作用，这一点正日益得到认可。在这篇综述文章中，我们评估了黄斑色素水平和分布的非侵入性定量对于识别可能因年龄相关性黄斑变性而面临视力残疾或灾难性视力丧失风险的个体的价值，并考虑了目前可用的各种测量方法的优缺点。
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1
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Invest Ophthalmol Vis Sci. 2012 Sep 14;53(10):6178-86. doi: 10.1167/iovs.12-10275.
2
Spectrophotometer for noninvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus.用于无创测量眼底固有荧光和反射率的分光光度计。
Appl Opt. 1994 Nov 1;33(31):7439-52. doi: 10.1364/AO.33.007439.
3
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Am J Clin Nutr. 2009 Nov;90(5):1272-9. doi: 10.3945/ajcn.2009.28013. Epub 2009 Sep 16.
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Comparison between macular pigment optical density measurements using two-wavelength autofluorescence and heterochromatic flicker photometry techniques.两种波长自荧光和对比闪烁光度测定技术测量黄斑色素密度的比较。
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3152-6. doi: 10.1167/iovs.09-3608. Epub 2009 Jul 2.
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