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传统日医学方枳术汤通过拮抗 5-HT(3)受体通路促进大鼠胃排空。

The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats.

机构信息

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

出版信息

Evid Based Complement Alternat Med. 2011;2011:248481. doi: 10.1093/ecam/nep173. Epub 2011 Feb 13.

DOI:10.1093/ecam/nep173
PMID:19861508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3095508/
Abstract

The traditional Japanese medicine rikkunshito ameliorates the nitric oxide-associated delay in gastric emptying. Whether rikkunshito affects gastric motility associated with 5-hydroxytryptamine (serotonin: 5-HT) receptors or dopamine receptors is unknown. We examined the effects of rikkunshito on the delay in gastric emptying induced by 5-HT or dopamine using the phenol red method in male Wistar rats. 5-HT (0.01-1.0 mg kg(-1), i.p.) dose dependently delayed gastric emptying, similar to the effect of the 5-HT(3) receptor agonist 1-(3-chlorophenyl) biguanide (0.01-1.0 mg kg(-1), i.p.). Dopamine also dose dependently delayed gastric emptying. The 5-HT(3) receptor antagonist ondansetron (0.04-4.0 mg kg(-1)) and rikkunshito (125-500 mg kg(-1)) significantly suppressed the delay in gastric emptying caused by 5-HT or 1-(3-chlorophenyl) biguanide. Hesperidin (the most active ingredient in rikkunshito) suppressed the 5-HT-induced delayed gastric emptying in a dose-dependent manner, the maximum effect of which was similar to that of ondansetron (0.4 mg kg(-1)). The improvement obtained by rikkunshito or ondansetron in delaying gastric emptying was completely blocked by pretreatment with atropine. Rikkunshito appears to improve delay in gastric emptying via the antagonistic action of the 5-HT(3) receptor pathway.

摘要

传统的日本医学方剂理气健脾汤可改善一氧化氮引起的胃排空延迟。理气健脾汤是否影响与 5-羟色胺（5-HT）受体或多巴胺受体相关的胃动力尚不清楚。我们使用酚红法在雄性 Wistar 大鼠中检查了理气健脾汤对 5-HT 或多巴胺引起的胃排空延迟的影响。5-HT（0.01-1.0mg/kg，ip）剂量依赖性地延迟胃排空，类似于 5-HT（3）受体激动剂 1-（3-氯苯基）胍（0.01-1.0mg/kg，ip）的作用。多巴胺也剂量依赖性地延迟胃排空。5-HT（3）受体拮抗剂昂丹司琼（0.04-4.0mg/kg）和理气健脾汤（125-500mg/kg）显著抑制 5-HT 或 1-（3-氯苯基）胍引起的胃排空延迟。橙皮苷（理气健脾汤中最有效的成分）以剂量依赖性方式抑制 5-HT 诱导的胃排空延迟，其最大效应类似于昂丹司琼（0.4mg/kg）。理气健脾汤或昂丹司琼改善胃排空延迟的作用完全被阿托品预处理阻断。理气健脾汤似乎通过拮抗 5-HT（3）受体途径来改善胃排空延迟。

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